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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2000-11-28
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pubmed:databankReference |
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pubmed:abstractText |
We characterized two immune escape viruses (SHIV(KU-1/105w52) and SHIV(KU-1/105w98)) from a macaque immunized with DeltavpuDeltanef SHIV-4 and challenged with pathogenic SHIV(KU-1). This macaque developed neutralizing antibodies as well as virus-specific CTLs against the challenge virus. However, the two new viruses could not be neutralized by anti-SHIV(KU-1)-specific neutralizing antibodies and were poorly recognized by challenge virus-specific CTLs. Sequence analysis of the gene encoding gp120 revealed several mutations in the protein that might have contributed to the development of the immune-escape viruses.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, nef,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/Human Immunodeficiency Virus...,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Regulatory and Accessory...,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/nef Gene Products, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/vpu protein, Human...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0889-2229
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1573-80
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11054270-Amino Acid Sequence,
pubmed-meshheading:11054270-Animals,
pubmed-meshheading:11054270-Antibodies, Viral,
pubmed-meshheading:11054270-Base Sequence,
pubmed-meshheading:11054270-DNA, Viral,
pubmed-meshheading:11054270-Gene Products, nef,
pubmed-meshheading:11054270-HIV Envelope Protein gp120,
pubmed-meshheading:11054270-HIV-1,
pubmed-meshheading:11054270-Human Immunodeficiency Virus Proteins,
pubmed-meshheading:11054270-Humans,
pubmed-meshheading:11054270-Macaca,
pubmed-meshheading:11054270-Molecular Sequence Data,
pubmed-meshheading:11054270-Mutagenesis,
pubmed-meshheading:11054270-Neutralization Tests,
pubmed-meshheading:11054270-Simian immunodeficiency virus,
pubmed-meshheading:11054270-Vaccination,
pubmed-meshheading:11054270-Viral Load,
pubmed-meshheading:11054270-Viral Regulatory and Accessory Proteins,
pubmed-meshheading:11054270-Viral Vaccines,
pubmed-meshheading:11054270-nef Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2000
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pubmed:articleTitle |
Characterization of immune escape viruses from a macaque immunized with live-virus vaccine and challenged with pathogenic SHIVKU-1.
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pubmed:affiliation |
Merrell Dow Laboratory of Viral Pathogenesis and Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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