| pubmed-article:11054111 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C0073337 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1307407 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1414805 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1705621 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1138405 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11054111 | lifeskim:mentions | umls-concept:C1136224 | lld:lifeskim |
| pubmed-article:11054111 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:11054111 | pubmed:dateCreated | 2000-12-5 | lld:pubmed |
| pubmed-article:11054111 | pubmed:abstractText | We have analysed the effect of transcription inhibitors on the polysomal localization of 5' terminal oligopyrimidine (TOP-) mRNAs. It is known that, in vertebrates, the translation of this group of mRNAs is regulated according to the growth status of the cell. Mitogenic stimulation of quiescent cells induces a rapid recruitment of TOP mRNAs from translationally inactive light messenger ribonucleoprotein particles to polysomes. It was found that administration of transcription inhibitors to resting cells causes a similar collective translational activation of TOP mRNAs, without affecting global translation. A number of transcription inhibitors were tested in amphibian and mammalian cultured cells. Actinomycin D (act D), cordycepin, and 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole caused a similar activation whereas alpha-amanitin or low doses of act D did not induce the translational response. Concentrations of act D sufficient to induce TOP mRNA translation also induce 40S ribosomal protein S6 kinases 1 (S6K1) activation. Moreover at these concentrations of act D increased phosphorylation of 4E-BP1 was also observed, indicating the involvement of FRAP/mTOR. Consistent with this observation, pretreatment of resting cells with rapamycin suppresses the activation of TOP mRNA translation induced by act D. These results indicate that the effect of act D on translation is mediated by the S6Ks through FRAP/mTOR. | lld:pubmed |
| pubmed-article:11054111 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11054111 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11054111 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11054111 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11054111 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11054111 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11054111 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:11054111 | pubmed:author | pubmed-author:ThomasGG | lld:pubmed |
| pubmed-article:11054111 | pubmed:author | pubmed-author:AmaldiFF | lld:pubmed |
| pubmed-article:11054111 | pubmed:author | pubmed-author:LoreniFF | lld:pubmed |
| pubmed-article:11054111 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11054111 | pubmed:volume | 267 | lld:pubmed |
| pubmed-article:11054111 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11054111 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11054111 | pubmed:pagination | 6594-601 | lld:pubmed |
| pubmed-article:11054111 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11054111 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11054111 | pubmed:articleTitle | Transcription inhibitors stimulate translation of 5' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway. | lld:pubmed |
| pubmed-article:11054111 | pubmed:affiliation | Dipartimento di Biologia, Universita' 'Tor Vergata', Roma, Italy; Department of Growth Control, Friedrich Miescher Institut, Basel, Switzerland. loreni@uniroma2.it | lld:pubmed |
| pubmed-article:11054111 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11054111 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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