Linked Life Data

11053482

Source:http://linkedlifedata.com/resource/pubmed/id/11053482

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2000-11-6
pubmed:abstractText
The impact of renin-angiotensin system (RAS) gene polymorphism on the prognosis of IgA nephropathy (IgAN) is still debated. A longitudinal study of renal prognosis in patients with IgAN was conducted to search retrospectively for a genotype-phenotype association between RAS polymorphisms and end-stage renal failure (ESRF). A classification based on serum creatinine (S(cr)) and 24-h proteinuria (24-P) measured at the time of renal biopsy was used to estimate the risk of ESRF in IgAN: stage 1 (S(cr) </= 150 micromol/L and 24-P < 1 g), stage 2 (S(cr) > 150 micromol/L and 24-P < 1 g or S(cr) < or = 150 micromol/L and 24-P > or = 1 g), stage 3 (S(cr) > 150 micromol/L and 24-P > or = 1 g). Deletion/insertion polymorphism (D/I) of the angiotensin I converting enzyme gene, M235T polymorphism (T/M) of the angiotensinogen gene and A1166C polymorphism (C/A) of the angiotensin II type 1 receptor gene were determined in 274 Caucasian men with biopsy-proven IgAN (n = 86, 112, and 76 in stages 1, 2, and 3, respectively). Mean global follow-up was 6 +/- 5 yr after renal biopsy. For stages 1, 2, and 3, ESRF developed in 7 (8. 1%), 39 (34.8%), and 49 (64.4%) cases (P: < 0.0001), 11.7 +/- 4, 5.4 +/- 4, and 2 +/- 2 yr, respectively, after renal biopsy (P: < 0.001). The distributions of the three genotypes into the three stages were similar. Different distributions were observed when patients were grouped by stage and genotype: ID+DD: 72% in stage 1 versus 84.6% in stages 2 + 3 (P: = 0.02; kappa = 0.14); MT+TT: 66.2% in stages 1 + 2 versus 78.9% in stage 3 (P: = 0.04; kappa = 0.09); and AA+AC: 89.9% in stages 1 + 2 versus 97.4% in stage 3 (P: = 0.04; kappa = -0.1). However, with the use of the Cox proportional hazard model, none of the three genotypes was found to have predictive value for renal survival. Compared with S(cr) and 24-P, genotypes DD, TT, and AA are unlikely to serve as clinically useful predictors of ESRF in IgAN.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1046-6673
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2062-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11053482-Adolescent, pubmed-meshheading:11053482-Adult, pubmed-meshheading:11053482-Aged, pubmed-meshheading:11053482-Aged, 80 and over, pubmed-meshheading:11053482-Angiotensinogen, pubmed-meshheading:11053482-Child, pubmed-meshheading:11053482-Genotype, pubmed-meshheading:11053482-Glomerulonephritis, IGA, pubmed-meshheading:11053482-Humans, pubmed-meshheading:11053482-Kidney Failure, Chronic, pubmed-meshheading:11053482-Longitudinal Studies, pubmed-meshheading:11053482-Male, pubmed-meshheading:11053482-Middle Aged, pubmed-meshheading:11053482-Peptidyl-Dipeptidase A, pubmed-meshheading:11053482-Polymorphism, Genetic, pubmed-meshheading:11053482-Predictive Value of Tests, pubmed-meshheading:11053482-Receptor, Angiotensin, Type 1, pubmed-meshheading:11053482-Receptor, Angiotensin, Type 2, pubmed-meshheading:11053482-Receptors, Angiotensin, pubmed-meshheading:11053482-Retrospective Studies, pubmed-meshheading:11053482-Survival Analysis
pubmed:year
2000
pubmed:articleTitle
Polymorphism of angiotensin converting enzyme, angiotensinogen, and angiotensin II type 1 receptor genes and end-stage renal failure in IgA nephropathy: IGARAS--a study of 274 Men.
pubmed:affiliation
Department of Nephrology, University Hospital, Nancy, France. l.frimat@chu-nancy.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't