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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2000-11-17
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pubmed:abstractText |
We developed micropore membrane inlet mass spectrometer (MMIMS) probes to rapidly measure inert-gas partial pressures in small blood samples. The mass spectrometer output was linearly related to inert-gas partial pressure (r(2) of 0.996-1.000) and was nearly independent of large variations in inert-gas solubility in liquid samples. We infused six inert gases into five pentobarbital-anesthetized New Zealand rabbits and used the MMIMS system to measure inert-gas partial pressures in systemic and pulmonary arterial blood and in mixed expired gas samples. The retention and excretion data were transformed into distributions of ventilation-to-perfusion ratios (V(A)/Q) with the use of linear regression techniques. Distributions of V(A)/Q were unimodal and broad, consistent with prior reports in the normal rabbit. Total blood sample volume for each VA/Q distribution was 4 ml, and analysis time was 8 min. MMIMS provides a convenient method to perform the multiple inert-gas elimination technique rapidly and with small blood sample volumes.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetone,
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Enflurane,
http://linkedlifedata.com/resource/pubmed/chemical/Ether, Ethyl,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/Krypton,
http://linkedlifedata.com/resource/pubmed/chemical/Membranes, Artificial,
http://linkedlifedata.com/resource/pubmed/chemical/Noble Gases,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfur Hexafluoride,
http://linkedlifedata.com/resource/pubmed/chemical/desflurane
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
8750-7587
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1699-708
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11053316-Acetone,
pubmed-meshheading:11053316-Anesthetics, Inhalation,
pubmed-meshheading:11053316-Animals,
pubmed-meshheading:11053316-Blood Gas Analysis,
pubmed-meshheading:11053316-Enflurane,
pubmed-meshheading:11053316-Ether, Ethyl,
pubmed-meshheading:11053316-Female,
pubmed-meshheading:11053316-Isoflurane,
pubmed-meshheading:11053316-Krypton,
pubmed-meshheading:11053316-Mass Spectrometry,
pubmed-meshheading:11053316-Membranes, Artificial,
pubmed-meshheading:11053316-Noble Gases,
pubmed-meshheading:11053316-Partial Pressure,
pubmed-meshheading:11053316-Pulmonary Artery,
pubmed-meshheading:11053316-Rabbits,
pubmed-meshheading:11053316-Sensitivity and Specificity,
pubmed-meshheading:11053316-Solubility,
pubmed-meshheading:11053316-Sulfur Hexafluoride,
pubmed-meshheading:11053316-Ventilation-Perfusion Ratio
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pubmed:year |
2000
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pubmed:articleTitle |
Sequential V(A)/Q distributions in the normal rabbit by micropore membrane inlet mass spectrometry.
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pubmed:affiliation |
Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania 19104-4283, USA. jbaumgar@mail.med.upenn.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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