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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2000-11-8
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pubmed:abstractText |
Proton pump inhibitors and antimicrobial agents are widely used to eradicate Helicobacter pylori (H. pylori) infection. In the general population the prevalence of infection and of polypharmacy increases the possibility of drug-drug interactions during H. pylori eradication therapy. The purpose of the present study was to assess the prevalence, degree, and clinical relevance of metabolic interference with the cytochrome P450 enzymatic system occurring during 1 wk of administration of omeprazole, lansoprazole, or pantoprazole followed by the association of clarithromycin and metronidazole for another week. The 13C aminopyrine breath test (ABT) was chosen to screen for possible interactions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Pyridinylmethylsulfinylbenzimidazo...,
http://linkedlifedata.com/resource/pubmed/chemical/Aminopyrine,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzimidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Clarithromycin,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Metronidazole,
http://linkedlifedata.com/resource/pubmed/chemical/Omeprazole,
http://linkedlifedata.com/resource/pubmed/chemical/Proton Pumps,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfoxides,
http://linkedlifedata.com/resource/pubmed/chemical/lansoprazole,
http://linkedlifedata.com/resource/pubmed/chemical/pantoprazole
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9270
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2762-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11051345-2-Pyridinylmethylsulfinylbenzimidazoles,
pubmed-meshheading:11051345-Adult,
pubmed-meshheading:11051345-Aged,
pubmed-meshheading:11051345-Aminopyrine,
pubmed-meshheading:11051345-Anti-Ulcer Agents,
pubmed-meshheading:11051345-Benzimidazoles,
pubmed-meshheading:11051345-Breath Tests,
pubmed-meshheading:11051345-Carbon Radioisotopes,
pubmed-meshheading:11051345-Clarithromycin,
pubmed-meshheading:11051345-Cytochrome P-450 Enzyme System,
pubmed-meshheading:11051345-Drug Therapy, Combination,
pubmed-meshheading:11051345-Female,
pubmed-meshheading:11051345-Gastritis,
pubmed-meshheading:11051345-Helicobacter Infections,
pubmed-meshheading:11051345-Helicobacter pylori,
pubmed-meshheading:11051345-Humans,
pubmed-meshheading:11051345-Male,
pubmed-meshheading:11051345-Metronidazole,
pubmed-meshheading:11051345-Middle Aged,
pubmed-meshheading:11051345-Omeprazole,
pubmed-meshheading:11051345-Peptic Ulcer,
pubmed-meshheading:11051345-Proton Pumps,
pubmed-meshheading:11051345-Sulfoxides
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pubmed:year |
2000
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pubmed:articleTitle |
Influence of Helicobacter pylori eradication therapy on 13C aminopyrine breath test: comparison among omeprazole-, lansoprazole-, or pantoprazole-containing regimens.
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pubmed:affiliation |
Department of Internal Medicine and Health Sciences, University of Genoa, Italy.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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