| pubmed-article:11050161 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11050161 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:11050161 | lifeskim:mentions | umls-concept:C0282151 | lld:lifeskim |
| pubmed-article:11050161 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:11050161 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:11050161 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:11050161 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11050161 | lifeskim:mentions | umls-concept:C1521871 | lld:lifeskim |
| pubmed-article:11050161 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:11050161 | pubmed:dateCreated | 2000-11-27 | lld:pubmed |
| pubmed-article:11050161 | pubmed:abstractText | Dopamine and cAMP-regulated phosphoprotein of M(r) 32,000 (DARPP-32) plays an obligatory role in most of the actions of dopamine. In resting neostriatal slices, cyclin-dependent kinase 5 (Cdk5) phosphorylates DARPP-32 at Thr-75, thereby reducing the efficacy of dopaminergic signaling. We report here that dopamine, in slices, and acute cocaine, in whole animals, decreases the state of phosphorylation of striatal DARPP-32 at Thr-75 and thereby removes this inhibitory constraint. This effect of dopamine is achieved through dopamine D1 receptor-mediated activation of cAMP-dependent protein kinase (PKA). The activated PKA, by decreasing the state of phosphorylation of DARPP-32-Thr-75, de-inhibits itself. Dopamine D2 receptor stimulation has the opposite effect. The ability of activated PKA to reduce the state of phosphorylation of DARPP-32-Thr-75 is apparently attributable to increased protein phosphatase-2A activity, with Cdk5 being unaffected. Together, these results indicate that via positive feedback mechanisms, Cdk5 signaling and PKA signaling are mutually antagonistic. | lld:pubmed |
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| pubmed-article:11050161 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11050161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050161 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11050161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11050161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11050161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11050161 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11050161 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11050161 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11050161 | pubmed:author | pubmed-author:NishiAA | lld:pubmed |
| pubmed-article:11050161 | pubmed:author | pubmed-author:GreengardPP | lld:pubmed |
| pubmed-article:11050161 | pubmed:author | pubmed-author:HigashiHH | lld:pubmed |
| pubmed-article:11050161 | pubmed:author | pubmed-author:NairnA CAC | lld:pubmed |
| pubmed-article:11050161 | pubmed:author | pubmed-author:SnyderG LGL | lld:pubmed |
| pubmed-article:11050161 | pubmed:author | pubmed-author:BibbJ AJA | lld:pubmed |
| pubmed-article:11050161 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11050161 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:11050161 | pubmed:volume | 97 | lld:pubmed |
| pubmed-article:11050161 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11050161 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11050161 | pubmed:pagination | 12840-5 | lld:pubmed |
| pubmed-article:11050161 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11050161 | pubmed:meshHeading | pubmed-meshheading:11050161... | lld:pubmed |
| pubmed-article:11050161 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11050161 | pubmed:articleTitle | Amplification of dopaminergic signaling by a positive feedback loop. | lld:pubmed |
| pubmed-article:11050161 | pubmed:affiliation | Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan. nishia@med.kurume-u.ac.jp | lld:pubmed |
| pubmed-article:11050161 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11050161 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11050161 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
