Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
265
pubmed:dateCreated
2000-11-21
pubmed:abstractText
Because of the absence of specific marker, the histological classification of gliomas remain controversial. Identifying the genetic alterations involved in gliomas makes it possible to define specific molecular pathway of tumoral progression and to define markers of prognostic and diagnostic relevance. For example, p53 mutations are frequent in low grade astrocytoma, anaplastic astrocytoma and secondary glioblastoma suggesting that it takes place at an early stage of development of astrocytic tumors, whereas inactivation of PTEN arises mainly in glioblastomas and EGFR amplification is preferentially associated with "de novo" glioblastoma. Loss of chromosomes 1p and 19q characterizes oligodendroglial tumors. However the putative tumor suppressor genes located on 1p and 19q and specifically inactivated are not known yet. Emerging technologies, like microarrays and microdissection, will allow to refine molecular data and provide a molecular classification of gliomas mechanism involved in the repair of the respiratory epithelium.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1286-0115
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-5
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11048299-Cell Cycle Proteins, pubmed-meshheading:11048299-Cell Transformation, Neoplastic, pubmed-meshheading:11048299-Central Nervous System Neoplasms, pubmed-meshheading:11048299-Chromosome Aberrations, pubmed-meshheading:11048299-Chromosome Deletion, pubmed-meshheading:11048299-Chromosomes, Human, pubmed-meshheading:11048299-Gene Expression Regulation, Neoplastic, pubmed-meshheading:11048299-Genes, Tumor Suppressor, pubmed-meshheading:11048299-Genes, cdc, pubmed-meshheading:11048299-Genes, p53, pubmed-meshheading:11048299-Genotype, pubmed-meshheading:11048299-Glioma, pubmed-meshheading:11048299-Humans, pubmed-meshheading:11048299-Neoplasm Proteins, pubmed-meshheading:11048299-Oligodendroglioma, pubmed-meshheading:11048299-Oncogenes, pubmed-meshheading:11048299-PTEN Phosphohydrolase, pubmed-meshheading:11048299-Phenotype, pubmed-meshheading:11048299-Phosphoric Monoester Hydrolases, pubmed-meshheading:11048299-Receptor, Epidermal Growth Factor, pubmed-meshheading:11048299-Tumor Suppressor Proteins
pubmed:year
2000
pubmed:articleTitle
[Genes implicated in glial tumors].
pubmed:affiliation
Fédération neurologique Mazarin et INSERM U495, Groupe hospitalier Pitié-Salpêtrière, Paris, France.
pubmed:publicationType
Journal Article, English Abstract, Review