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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-11-2
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pubmed:abstractText |
Recent studies indicate an expression of mitogen-inducible cyclooxygenase (COX-2) in gastric mucosa. Rebamipide, a mucoprotective agent enhances prostaglandin (PG) synthesis. The present study was designed to clarify the mechanism for rebamipide-induced mucosal protection. Male Sprague-Dawley rats were administered 5, 15, or 50 mg/kg/day rebamipide for 14 days. The expression of constitutive cyclooxygenase (COX-1) and COX-2 in gastric mucosa was determined using Western blot analysis. Another series of rats was used to examine 1) the levels of PGE(2) in stomach with and without pretreatment with a COX-2 inhibitor; 2) the protective action of rebamipide against gastric damage caused by 0.6 N HCl; and 3) the effects of a COX-2 inhibitor on rebamipide-induced gastric mucosal protection. COX-2 expression was enhanced, whereas COX-1 expression did not change significantly in the gastric mucosa of rats after treatment with rebamipide. The gastric mucosal PGE(2) was higher in the rebamipide groups than in the vehicle-treated group. Rebamipide also suppressed gastric damage induced by HCl in a dose-dependent manner. A COX-2 inhibitor blocked the rebamipide-induced increase in mucosal PGE(2), and mucosal protection induced by rebamipide. The results indicate that rebamipide induces COX-2 expression, increases PGE(2) levels, and enhances gastric mucosal defense in a COX-2-dependent manner. Thus, COX-2 has an important role in the effects of rebamipide on gastric mucosal protection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrochloric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptgs1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolones,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/rebamipide
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-3565
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pubmed:author |
pubmed-author:FuxJ PJP,
pubmed-author:GunawanE SES,
pubmed-author:HoriMM,
pubmed-author:IijimaHH,
pubmed-author:KakiuchiYY,
pubmed-author:KawaiNN,
pubmed-author:KawanoSS,
pubmed-author:KimuraAA,
pubmed-author:OkudaYY,
pubmed-author:SasakiYY,
pubmed-author:TsujiSS,
pubmed-author:TsujiiMM,
pubmed-author:YasumaruMM
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pubmed:issnType |
Print
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pubmed:volume |
295
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-52
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11046075-Alanine,
pubmed-meshheading:11046075-Animals,
pubmed-meshheading:11046075-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:11046075-Anti-Ulcer Agents,
pubmed-meshheading:11046075-Cyclooxygenase 1,
pubmed-meshheading:11046075-Cyclooxygenase 2,
pubmed-meshheading:11046075-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:11046075-Cyclooxygenase Inhibitors,
pubmed-meshheading:11046075-Dinoprostone,
pubmed-meshheading:11046075-Drug Interactions,
pubmed-meshheading:11046075-Enzyme Induction,
pubmed-meshheading:11046075-Enzyme Inhibitors,
pubmed-meshheading:11046075-Gastric Mucosa,
pubmed-meshheading:11046075-Hydrochloric Acid,
pubmed-meshheading:11046075-Isoenzymes,
pubmed-meshheading:11046075-Male,
pubmed-meshheading:11046075-Membrane Proteins,
pubmed-meshheading:11046075-Nitrobenzenes,
pubmed-meshheading:11046075-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:11046075-Quinolones,
pubmed-meshheading:11046075-Rats,
pubmed-meshheading:11046075-Rats, Sprague-Dawley,
pubmed-meshheading:11046075-Stomach Ulcer,
pubmed-meshheading:11046075-Sulfonamides,
pubmed-meshheading:11046075-Up-Regulation
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pubmed:year |
2000
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pubmed:articleTitle |
Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent.
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pubmed:affiliation |
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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