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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2000-11-3
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pubmed:abstractText |
Infection of B6 mice with the intracellular pathogen Listeria monocytogenes (LM) results in the activation of CD8(+) T cells that respond to Ag presented by both MHC class Ia and class Ib molecules. Enzyme-linked immunospot analysis reveals that these CTL populations expand and contract at different times following a primary sublethal LM infection. Between days 4 and 6 postinfection, class Ib-restricted CTL exhibit a rapid proliferative response that is primarily H2-M3 restricted. The peak response of class Ia-restricted CD8(+) T cells occurs a few days later, after the majority of bacteria have been cleared. Although class Ia-restricted CTL exhibit a vigorous recall response to secondary LM infection, we observe limited expansion of class Ib-restricted memory CTL, even in MHC class Ia-deficient mice (B6.K(b-/-)D(b-/-)). Despite this lack of enhanced expansion in vivo, class Ib-restricted memory CTL retain the ability to proliferate and expand when provided with Ag in vitro. Furthermore, we demonstrate that in vivo depletion of CD8(+) T cells in LM-immune B6.K(b-/-)D(b-/-) mice severely impairs memory protection. Together, these data demonstrate that class Ib-restricted CTL play an important role in clearing a primary LM infection and generate a memory population capable of providing significant protection against subsequent infection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/H-2K(K) antigen,
http://linkedlifedata.com/resource/pubmed/chemical/H-2Kb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/H2-M antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-D Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DM antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
165
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5192-201
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11046052-Animals,
pubmed-meshheading:11046052-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11046052-Cell Line,
pubmed-meshheading:11046052-Cells, Cultured,
pubmed-meshheading:11046052-Cytotoxicity, Immunologic,
pubmed-meshheading:11046052-Epitopes, T-Lymphocyte,
pubmed-meshheading:11046052-H-2 Antigens,
pubmed-meshheading:11046052-HLA-D Antigens,
pubmed-meshheading:11046052-Histocompatibility Antigens Class II,
pubmed-meshheading:11046052-Immunization, Secondary,
pubmed-meshheading:11046052-Immunodominant Epitopes,
pubmed-meshheading:11046052-Immunologic Memory,
pubmed-meshheading:11046052-Immunophenotyping,
pubmed-meshheading:11046052-Kinetics,
pubmed-meshheading:11046052-Listeria monocytogenes,
pubmed-meshheading:11046052-Listeriosis,
pubmed-meshheading:11046052-Lymphocyte Activation,
pubmed-meshheading:11046052-Mice,
pubmed-meshheading:11046052-Mice, Inbred C57BL,
pubmed-meshheading:11046052-Mice, Knockout,
pubmed-meshheading:11046052-T-Lymphocyte Subsets,
pubmed-meshheading:11046052-T-Lymphocytes, Cytotoxic
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pubmed:year |
2000
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pubmed:articleTitle |
MHC class Ib-restricted CTL provide protection against primary and secondary Listeria monocytogenes infection.
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pubmed:affiliation |
Immunology Graduate Program and Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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