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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-2-13
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pubmed:abstractText |
Chronic granulomatous diseases (CGD) are caused by impaired antimicrobial activity in phagocytes, due to the absence or malfunction of the respiratory burst NADPH oxidase. Two-thirds of the patients have mutations in their X-linked CGD gene encoding gp91phox, the largest subunit of the NADPH oxidase.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
317-25
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11045425-Cell Differentiation,
pubmed-meshheading:11045425-Cell Line,
pubmed-meshheading:11045425-Gene Expression,
pubmed-meshheading:11045425-Gene Transfer Techniques,
pubmed-meshheading:11045425-Genes, Reporter,
pubmed-meshheading:11045425-Genetic Vectors,
pubmed-meshheading:11045425-Granulocytes,
pubmed-meshheading:11045425-Granulomatous Disease, Chronic,
pubmed-meshheading:11045425-Green Fluorescent Proteins,
pubmed-meshheading:11045425-HIV-1,
pubmed-meshheading:11045425-Humans,
pubmed-meshheading:11045425-Lentivirus,
pubmed-meshheading:11045425-Luminescent Proteins,
pubmed-meshheading:11045425-Membrane Glycoproteins,
pubmed-meshheading:11045425-Mutation,
pubmed-meshheading:11045425-NADPH Oxidase,
pubmed-meshheading:11045425-Phenotype,
pubmed-meshheading:11045425-Transduction, Genetic,
pubmed-meshheading:11045425-Vesicular stomatitis Indiana virus
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pubmed:articleTitle |
Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells.
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pubmed:affiliation |
Division of Immunology/Hematology, University Children's Hospital, Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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