Linked Life Data

11045041

Source:http://linkedlifedata.com/resource/pubmed/id/11045041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-12-11
pubmed:abstractText
The normal development and function of the prostate, as well as its pathological growth, are governed by a lifelong dependency on endogenous androgens, the majority of which are of testicular origin. In contrast to other androgen-sensitive tissues, androgenic effects in the prostate are only exerted by the intracellular metabolite dihydrotestosterone. Conflicting evidence exists regarding changes of the intracellular prostatic androgen receptors in benign prostatic hyperplasia and prostatic carcinoma. Equally conflicting is the clinical evidence concerning androgen metabolism in patients with manifest or metastatic prostate cancer. So far, there is no clear evidence for an increased risk of prostatic neoplasia with testosterone substitution in absolute or partial androgen deficiency. However, in view of the high prevalence of latent prostate cancer, caution is advisable.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0340-2592
pubmed:author
pubmed:issnType
Print
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
418-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
[Testosterone and the prostate].
pubmed:affiliation
Klinik und Poliklinik für Urologie, Universitätsklinikum Carl-Gustav Carus, Technische Universität Dresden.
pubmed:publicationType
Journal Article, English Abstract, Review