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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2000-10-30
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pubmed:abstractText |
In the pathogenesis of cardiac dysfunction in heart failure, a decrease in the activity of the sarcoplasmic reticulum (SR) Ca(2+)-ATPase is believed to be a major determinant. Here, we report a novel mechanism of cardiac dysfunction revealed by assessing the functional interaction of FK506-binding protein (FKBP12.6) with the cardiac ryanodine receptor (RyR) in a canine model of pacing-induced heart failure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:HisamatsuYY,
pubmed-author:HisaokaTT,
pubmed-author:KobayashiSS,
pubmed-author:KohnoMM,
pubmed-author:MatsuzakiMM,
pubmed-author:NoguchiNN,
pubmed-author:OhkusaTT,
pubmed-author:OkamotoHH,
pubmed-author:OnoKK,
pubmed-author:SuetsuguMM,
pubmed-author:TakasawaSS,
pubmed-author:YamamotoTT,
pubmed-author:YanoMM
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2131-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11044432-Animals,
pubmed-meshheading:11044432-Calcium,
pubmed-meshheading:11044432-Cardiac Output, Low,
pubmed-meshheading:11044432-Disease Models, Animal,
pubmed-meshheading:11044432-Dogs,
pubmed-meshheading:11044432-Female,
pubmed-meshheading:11044432-Male,
pubmed-meshheading:11044432-Pacemaker, Artificial,
pubmed-meshheading:11044432-Protein Conformation,
pubmed-meshheading:11044432-Ryanodine,
pubmed-meshheading:11044432-Ryanodine Receptor Calcium Release Channel,
pubmed-meshheading:11044432-Sarcoplasmic Reticulum,
pubmed-meshheading:11044432-Tacrolimus,
pubmed-meshheading:11044432-Tacrolimus Binding Proteins,
pubmed-meshheading:11044432-Tritium
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pubmed:year |
2000
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pubmed:articleTitle |
Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure.
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pubmed:affiliation |
Second Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan. yanoma@po.cc.yamaguchi-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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