| pubmed-article:11044406 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C0035507 | lld:lifeskim |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C0521422 | lld:lifeskim |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C0016026 | lld:lifeskim |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C1414315 | lld:lifeskim |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11044406 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11044406 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:11044406 | pubmed:dateCreated | 2000-12-8 | lld:pubmed |
| pubmed-article:11044406 | pubmed:abstractText | Krox20 and mafB/kr are regulatory genes involved in hindbrain segmentation and anteroposterior (AP) patterning. They are expressed in rhombomeres (r) r3/r5 and r5/r6 respectively, as well as in the r5/r6 neural crest. Since several members of the fibroblast growth factor (FGF) family are expressed in the otic/preotic region (r2-r6), we investigated their possible involvement in the regulation of Krox20 and mafB/kr. Application of exogenous FGFs to the neural tube of 4- to 7-somite chick embryos led to ectopic expression in the neural crest of the somitic hindbrain (r7 and r8) and to the extension of the Krox20- or mafB/kr-positive areas in the neuroepithelium. Application of an inhibitor of FGF signalling led to severe and specific downregulation of Krox20 and mafB/kr in the hindbrain neuroepithelium and neural crest. These data indicate that FGFs are involved in the control of regional induction and/or maintenance of Krox20 and mafB/kr expression, thus identifying a novel function for these factors in hindbrain development, besides their proposed more general role in early neural caudalisation. | lld:pubmed |
| pubmed-article:11044406 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11044406 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11044406 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11044406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11044406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11044406 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11044406 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11044406 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11044406 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:11044406 | pubmed:author | pubmed-author:CharnayPP | lld:pubmed |
| pubmed-article:11044406 | pubmed:author | pubmed-author:MarínFF | lld:pubmed |
| pubmed-article:11044406 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11044406 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:11044406 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11044406 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11044406 | pubmed:pagination | 4925-35 | lld:pubmed |
| pubmed-article:11044406 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11044406 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11044406 | pubmed:articleTitle | Hindbrain patterning: FGFs regulate Krox20 and mafB/kr expression in the otic/preotic region. | lld:pubmed |
| pubmed-article:11044406 | pubmed:affiliation | Unité 368 de l'Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure, 75230 Paris Cedex 05, France. | lld:pubmed |
| pubmed-article:11044406 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11044406 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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