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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2000-12-8
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pubmed:abstractText |
Krox20 and mafB/kr are regulatory genes involved in hindbrain segmentation and anteroposterior (AP) patterning. They are expressed in rhombomeres (r) r3/r5 and r5/r6 respectively, as well as in the r5/r6 neural crest. Since several members of the fibroblast growth factor (FGF) family are expressed in the otic/preotic region (r2-r6), we investigated their possible involvement in the regulation of Krox20 and mafB/kr. Application of exogenous FGFs to the neural tube of 4- to 7-somite chick embryos led to ectopic expression in the neural crest of the somitic hindbrain (r7 and r8) and to the extension of the Krox20- or mafB/kr-positive areas in the neuroepithelium. Application of an inhibitor of FGF signalling led to severe and specific downregulation of Krox20 and mafB/kr in the hindbrain neuroepithelium and neural crest. These data indicate that FGFs are involved in the control of regional induction and/or maintenance of Krox20 and mafB/kr expression, thus identifying a novel function for these factors in hindbrain development, besides their proposed more general role in early neural caudalisation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 8,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/MafB Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/maf-B protein, chicken
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0950-1991
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4925-35
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11044406-Animals,
pubmed-meshheading:11044406-Avian Proteins,
pubmed-meshheading:11044406-Body Patterning,
pubmed-meshheading:11044406-Chick Embryo,
pubmed-meshheading:11044406-Chimera,
pubmed-meshheading:11044406-DNA-Binding Proteins,
pubmed-meshheading:11044406-Early Growth Response Protein 2,
pubmed-meshheading:11044406-Fibroblast Growth Factor 2,
pubmed-meshheading:11044406-Fibroblast Growth Factor 4,
pubmed-meshheading:11044406-Fibroblast Growth Factor 8,
pubmed-meshheading:11044406-Fibroblast Growth Factors,
pubmed-meshheading:11044406-In Situ Hybridization,
pubmed-meshheading:11044406-MafB Transcription Factor,
pubmed-meshheading:11044406-Neural Crest,
pubmed-meshheading:11044406-Oncogene Proteins,
pubmed-meshheading:11044406-Proto-Oncogene Proteins,
pubmed-meshheading:11044406-Quail,
pubmed-meshheading:11044406-Recombinant Proteins,
pubmed-meshheading:11044406-Rhombencephalon,
pubmed-meshheading:11044406-Trans-Activators,
pubmed-meshheading:11044406-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Hindbrain patterning: FGFs regulate Krox20 and mafB/kr expression in the otic/preotic region.
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pubmed:affiliation |
Unité 368 de l'Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure, 75230 Paris Cedex 05, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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