Source:http://linkedlifedata.com/resource/pubmed/id/11044278
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2000-10-26
|
| pubmed:abstractText |
We studied hepatitis B virus (HBV) transmission among 7416 Thai children from 148 schools in Kamphaeng Phet province, a rural part of northern Thailand. Their age ranged from 2 to 16 years (median 9 years). Between May 1991 and June 1992, 61 of 2593 (2.4%) in the cohort of susceptible children acquired anti-HBc immunoglobulin. Forty-seven of the 148 schools had children who acquired anti-HBc. School seroconversion rates to anti-HBc varied from 0% to 23%. There was no correlation between percent of carriers in schools and percent of anti-HBc acquisition. Of the 61 children who acquired anti-HBc, eight (13%) became HBsAg carriers but only two were symptomatic, for a clinical to subclinical infection ration of 1 : 30. One of the two symptomatic children became an HBsAg carrier. Three (38%) of the eight who were persistently antigenemic developed antibody to hepatitis B virus e antigen. Males were 2.5 times (95% CI 1.4-4.3) more likely to acquire anti-HBc than females. Risk factors for acquisition of HBc in Thailand over a 9-month period were examined in a subset of 2412 susceptible children and later in a case-control study of 22 children who acquired anti-HBc and 59 age and sex-matched controls. Risks for acquiring anti-HBc were male gender and a history of bleeding gums. In comparing this study to an earlier pilot study among 9848 children from the same area in Thailand, the yearly antibody acquisition rate to anti-HBc among Thai children dropped from 5.7% in 1989 to 2.4% in 1992. A random sample of children in the pilot study showed that 16% were HBsAg positive and 27% had anti-HBc at the beginning of the study. 34% had markers for either anti-HBc or HBsAg. 12% were repeatedly positive for HBsAg a year later.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1360-2276
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
633-9
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11044278-Adolescent,
pubmed-meshheading:11044278-Carrier State,
pubmed-meshheading:11044278-Case-Control Studies,
pubmed-meshheading:11044278-Child,
pubmed-meshheading:11044278-Child, Preschool,
pubmed-meshheading:11044278-Disease Transmission, Infectious,
pubmed-meshheading:11044278-Female,
pubmed-meshheading:11044278-Hepatitis B,
pubmed-meshheading:11044278-Hepatitis B Antibodies,
pubmed-meshheading:11044278-Hepatitis B Surface Antigens,
pubmed-meshheading:11044278-Hepatitis B e Antigens,
pubmed-meshheading:11044278-Hepatitis B virus,
pubmed-meshheading:11044278-Humans,
pubmed-meshheading:11044278-Incidence,
pubmed-meshheading:11044278-Male,
pubmed-meshheading:11044278-Matched-Pair Analysis,
pubmed-meshheading:11044278-Pilot Projects,
pubmed-meshheading:11044278-Prevalence,
pubmed-meshheading:11044278-Risk Factors,
pubmed-meshheading:11044278-Rural Health,
pubmed-meshheading:11044278-Sex Factors,
pubmed-meshheading:11044278-Thailand
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Hepatitis B virus infection in Thai children.
|
| pubmed:affiliation |
Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|