Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2000-11-21
pubmed:abstractText
Based on the human immunodeficiency virus type 1 (HIV-1) gag gene, subgenomic reporter constructs have been established allowing the contributions of different cis-acting elements to the Rev dependency of late HIV-1 gene products to be determined. Modification of intragenic regulatory elements achieved by adapting the codon usage of the complete gene to highly expressed mammalian genes resulted in constitutive nuclear export allowing high levels of Gag expression independent from the Rev/Rev-responsive element system and irrespective of the absence or presence of the isolated major splice donor. Leptomycin B inhibitor studies revealed that the RNAs derived from the codon-optimized gag gene lacking AU-rich inhibitory elements are directed to a distinct, CRM1-independent, nuclear export pathway.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-10364378, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-10518602, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-1433510, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-1448921, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-1656066, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-1727477, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-1895385, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-1913815, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-2217190, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-2686839, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-2704072, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-2832844, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-3040055, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-4705382, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-7491762, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-7510434, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-7512159, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-7543368, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-7592605, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-8151769, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-8289397, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-8331728, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-8578590, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-8609621, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9023367, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9188551, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9190288, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9384386, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9683540, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9696859, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9765402, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9811683, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9837918, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044131-9891806
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10822-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Concerted action of multiple cis-acting sequences is required for Rev dependence of late human immunodeficiency virus type 1 gene expression.
pubmed:affiliation
Institute of Medical Microbiology and Hygiene, University of Regensburg, D-93053 Regensburg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't