Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2000-11-21
pubmed:abstractText
The role of gamma interferon (IFN-gamma) in the permanent control of infection with a noncytopathic virus was studied by comparing immune responses in wild-type and IFN-gamma-deficient (IFN-gamma -/-) mice infected with a slowly invasive strain of lymphocytic choriomeningitis virus (LCMV Armstrong). While wild-type mice rapidly cleared the infection, IFN-gamma -/- mice became chronically infected. Virus persistence in the latter mice did not reflect failure to generate cytotoxic T-lymphocyte (CTL) effectors, as an unimpaired primary CTL response was observed. Furthermore, while ex vivo CTL activity gradually declined in wild-type mice, long-standing cytolytic activity was demonstrated in IFN-gamma -/- mice. The prolonged effector phase in infected IFN-gamma -/- mice was associated with elevated numbers of CD8(+) T cells. Moreover, a higher proportion of these cells retained an activated phenotype and was actively cycling. However, despite the increased CD8(+) T-cell turnover, which might have resulted in depletion of the memory CTL precursor pool, no evidence for exhaustion was observed. In fact, at 3 months postinfection we detected higher numbers of LCMV-specific CTL precursors in IFN-gamma -/- mice than in wild-type mice. These findings indicate that in the absence of IFN-gamma, CTLs cannot clear the infection and are kept permanently activated by the continuous presence of live virus, resulting in a delicate new balance between viral load and immunity. This interpretation of our findings is supported by mathematical modeling describing the effect of eliminating IFN-gamma-mediated antiviral activity on the dynamics between virus replication and CTL activity.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-10097126, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-10201909, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-10322301, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-10411921, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-10464167, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-10518559, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-10570301, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-1372370, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-2471775, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-2477254, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-2503388, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-2514255, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-2783710, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-2835246, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-4709270, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-4965698, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-6332167, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7507962, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7526382, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7531218, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7533855, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7543210, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7609046, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7676639, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7911534, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7939408, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-7966595, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8009221, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8164737, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8176216, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8456300, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8456301, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8469287, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8499074, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8658169, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8782700, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8794015, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8816417, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-8971031, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9126248, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9164957, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9192659, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9416507, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9548456, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9565629, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9584143, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9696840, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9733817, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9794385, http://linkedlifedata.com/resource/pubmed/commentcorrection/11044074-9858507
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10304-11
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Persistent virus infection despite chronic cytotoxic T-lymphocyte activation in gamma interferon-deficient mice infected with lymphocytic choriomeningitis virus.
pubmed:affiliation
Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't