Source:http://linkedlifedata.com/resource/pubmed/id/11042682
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
43
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| pubmed:dateCreated |
2000-10-26
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| pubmed:abstractText |
Adult T cell leukemia (ATLL) develops in 3 - 5% of HTLV-1 carriers after a long period of latency during which a persistent polyclonal expansion of HTLV-1 infected lymphocytes is observed in all individuals. This incubation period is significantly shortened in HTLV-1 carrier with Strongyloides stercoralis (Ss) infection, suggesting that Ss could be a cofactor of ATLL. As an increased T cell proliferation at the asymptomatic stage of HTLV-1 infection could increase the risk of malignant transformation, the effect of Ss infection on infected T lymphocytes was assessed in vivo in HTLV-1 asymptomatic carriers. After real-time quantitative PCR, the mean circulating HTLV-1 proviral load was more than five times higher in HTLV-1 carriers with strongyloidiasis than in HTLV-1+ individuals without Ss infection (P<0.009). This increased proviral load was found to result from the extensive proliferation of a restricted number of infected clones, i.e. from oligoclonal expansion, as evidenced by the semiquantitative amplification of HTLV-1 flanking sequences. The positive effect of Ss on clonal expansion was reversible under effective treatment of strongyloidiasis in one patient with parasitological cure whereas no significant modification of the HTLV-1 replication pattern was observed in an additional case with strongyloidiasis treatment failure. Therefore, Ss stimulates the oligoclonal proliferation of HTLV-1 infected cells in HTLV-1 asymptomatic carriers in vivo. This is thought to account for the shortened period of latency observed in ATLL patients with strongyloidiasis. Oncogene (2000) 19, 4954 - 4960
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0950-9232
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
12
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| pubmed:volume |
19
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4954-60
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11042682-Adult,
pubmed-meshheading:11042682-Aged,
pubmed-meshheading:11042682-Aged, 80 and over,
pubmed-meshheading:11042682-Animals,
pubmed-meshheading:11042682-Antinematodal Agents,
pubmed-meshheading:11042682-Carrier State,
pubmed-meshheading:11042682-Child,
pubmed-meshheading:11042682-Clone Cells,
pubmed-meshheading:11042682-Female,
pubmed-meshheading:11042682-Human T-lymphotropic virus 1,
pubmed-meshheading:11042682-Humans,
pubmed-meshheading:11042682-Lymphocyte Activation,
pubmed-meshheading:11042682-Male,
pubmed-meshheading:11042682-Middle Aged,
pubmed-meshheading:11042682-Polymerase Chain Reaction,
pubmed-meshheading:11042682-Proviruses,
pubmed-meshheading:11042682-Strongyloides stercoralis,
pubmed-meshheading:11042682-Strongyloidiasis,
pubmed-meshheading:11042682-T-Lymphocytes,
pubmed-meshheading:11042682-Thiabendazole,
pubmed-meshheading:11042682-Viral Load,
pubmed-meshheading:11042682-Virus Replication
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
High circulating proviral load with oligoclonal expansion of HTLV-1 bearing T cells in HTLV-1 carriers with strongyloidiasis.
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| pubmed:affiliation |
Unité d'Oncogenèse Virale, UMR5537 CNRS-Université Claude Bernard, Centre Léon Bérard, 28 rue Laënnec 69373, Lyon Cedex 08, France.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|