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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-11-20
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pubmed:abstractText |
Loss of heterozygosity (LOH) at chromosome 10q25-q26 has been reported previously in endometrial carcinoma (EC), suggesting the presence of tumor suppressor gene(s). Nevertheless, frequency of genome-wide microsatellite instability (MSI) has been demonstrated higher in EC than in other common malignancy, mostly due to defective DNA mismatch repair. The authors further evaluated the role of the chromosome 10q25-q26 in endometrial tumorigenesis as well as the clinical significance of any observed genetic alteration in sporadic EC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-543X
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pubmed:author |
pubmed-author:CherchiPP,
pubmed-author:CostePP,
pubmed-author:DessoleSS,
pubmed-author:MancaAA,
pubmed-author:MassarelliGG,
pubmed-author:PalmieriGG,
pubmed-author:PintusAA,
pubmed-author:PirastuMM,
pubmed-author:PisanoMM,
pubmed-author:RuiuGG,
pubmed-author:TandaFF
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pubmed:copyrightInfo |
Copyright 2000 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1773-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11042573-Adult,
pubmed-meshheading:11042573-Aged,
pubmed-meshheading:11042573-Aged, 80 and over,
pubmed-meshheading:11042573-Chromosome Mapping,
pubmed-meshheading:11042573-Chromosomes, Human, Pair 10,
pubmed-meshheading:11042573-DNA, Neoplasm,
pubmed-meshheading:11042573-Endometrial Neoplasms,
pubmed-meshheading:11042573-Female,
pubmed-meshheading:11042573-Genetic Markers,
pubmed-meshheading:11042573-Humans,
pubmed-meshheading:11042573-Italy,
pubmed-meshheading:11042573-Loss of Heterozygosity,
pubmed-meshheading:11042573-Microsatellite Repeats,
pubmed-meshheading:11042573-Middle Aged,
pubmed-meshheading:11042573-Neoplasm Staging,
pubmed-meshheading:11042573-Polymerase Chain Reaction
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pubmed:year |
2000
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pubmed:articleTitle |
Microsatellite analysis at 10q25-q26 in Sardinian patients with sporadic endometrial carcinoma: identification of specification patterns of genetic alteration.
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pubmed:affiliation |
Institute of Molecular Genetics, C.N.R., Alghero, Italy. gpalmieri@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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