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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
2000-11-3
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pubmed:abstractText |
The X gene product of the human hepatitis B virus (HBx), a major factor responsible for hepatitis and hepatocellular carcinoma, modulates transactivation by a variety of transcription factors. Herein, expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene was found to be regulated transcriptionally by HBx through two distinct promoter regions. The cAMP response element (CRE)-1 site within the proximal promoter region mediated the HBx-induced transactivation of the PEPCK gene through C/EBP alpha and ATF-2. A retinoid X receptor (RXR) response element within the distal promoter region also contributed to the HBx-induced transactivation. Consistent with these results, HBx directly interacted with RXR, and the interaction interfaces were localized to the transactivation domain of HBx and the ligand binding domain of RXR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoenolpyruvate Carboxykinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoid X Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/alitretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/hepatitis B virus X protein
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
483
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
114-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11042264-Activating Transcription Factor 2,
pubmed-meshheading:11042264-Binding Sites,
pubmed-meshheading:11042264-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:11042264-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:11042264-HeLa Cells,
pubmed-meshheading:11042264-Humans,
pubmed-meshheading:11042264-Phosphoenolpyruvate Carboxykinase (GTP),
pubmed-meshheading:11042264-Promoter Regions, Genetic,
pubmed-meshheading:11042264-Protein Binding,
pubmed-meshheading:11042264-Receptors, Retinoic Acid,
pubmed-meshheading:11042264-Retinoid X Receptors,
pubmed-meshheading:11042264-Trans-Activators,
pubmed-meshheading:11042264-Transcription, Genetic,
pubmed-meshheading:11042264-Transcription Factors,
pubmed-meshheading:11042264-Transcriptional Activation,
pubmed-meshheading:11042264-Tretinoin,
pubmed-meshheading:11042264-Tumor Cells, Cultured,
pubmed-meshheading:11042264-Two-Hybrid System Techniques
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pubmed:year |
2000
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pubmed:articleTitle |
Direct binding of hepatitis B virus X protein and retinoid X receptor contributes to phosphoenolpyruvate carboxykinase gene transactivation.
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pubmed:affiliation |
Center for Ligand and Transcription, Chonnam National University, Kwangju, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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