Source:http://linkedlifedata.com/resource/pubmed/id/11041555
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2001-1-17
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| pubmed:abstractText |
This study aimed to assess the relevance of specific potassium channels, such as inwardly or outwardly rectifying and calcium-regulated potassium channels, to the control of renin secretion. For this purpose we examined the effects of the K+ channel blockers 4-aminopyridine (1 mmol/l), barium (100 micromol/l), tetraethylammonium (2 mmol/l) and apamin (200 nmol/l) on basal renin secretion, on renin secretion stimulated by isoproterenol (10 nmol/l) and on the inhibition of renin secretion by angiotensin II (100-300 pmol/l) in the isolated rat kidney perfused at constant pressure. Whilst all four K+ channel blockers increased renal vascular resistance, only 4-aminopyridine and barium attenuated isoproterenol-stimulated renin secretion in an additive fashion and augmented the inhibitory effect of angiotensin II. These effects of K+ channel blockers were not changed by the L-type calcium channel blocker amlodipine (5 pmol/l), indicating that their effects on renin secretion are not due to voltage-operated calcium influx. Our data, moreover, suggest that potassium efflux from renal juxtaglomerular cells is not important for the inhibitory action of angiotensin II on renin secretion. As a consequence it appears that the membrane potential of renal juxtaglomerular cells per se is relevant to renin secretion such that membrane depolarization inhibits the exocytosis of renin whilst hyperpolarization favors renin secretion. By their activity, potassium channels can contribute to membrane hyperpolarization and thus facilitate renin secretion.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-Aminopyridine,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Apamin,
http://linkedlifedata.com/resource/pubmed/chemical/Barium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetraethylammonium,
http://linkedlifedata.com/resource/pubmed/chemical/barium chloride
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0031-6768
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
440
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
889-95
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11041555-4-Aminopyridine,
pubmed-meshheading:11041555-Adrenergic beta-Agonists,
pubmed-meshheading:11041555-Angiotensin II,
pubmed-meshheading:11041555-Animals,
pubmed-meshheading:11041555-Apamin,
pubmed-meshheading:11041555-Barium Compounds,
pubmed-meshheading:11041555-Chlorides,
pubmed-meshheading:11041555-Exocytosis,
pubmed-meshheading:11041555-Isoproterenol,
pubmed-meshheading:11041555-Kidney,
pubmed-meshheading:11041555-Male,
pubmed-meshheading:11041555-Membrane Potentials,
pubmed-meshheading:11041555-Potassium Channel Blockers,
pubmed-meshheading:11041555-Potassium Channels,
pubmed-meshheading:11041555-Rats,
pubmed-meshheading:11041555-Rats, Sprague-Dawley,
pubmed-meshheading:11041555-Renin,
pubmed-meshheading:11041555-Tetraethylammonium
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| pubmed:year |
2000
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| pubmed:articleTitle |
Role of potassium channels in the control of renin secretion from isolated perfused rat kidneys.
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| pubmed:affiliation |
Institut für Physiologie der Universität Regensburg, Germany. armin.kurtz@vkl.uni-regensburg.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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