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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-11-9
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pubmed:abstractText |
The occurrence of myeloid leukaemia in patients with systemic mastocytosis is a well recognised phenomenon. However, the pathophysiological basis of such a coevolution has not been clarified. Recent data have shown that the c-kit mutation Asp 816 to Val is detectable in neoplastic mast cells in most patients with systemic mastocytosis, including those who have associated haematological disorders. The aim of this study was to study clonal disease evolution by analysing bone marrow cells from a patient with systemic mastocytosis and associated chronic myelomonocytic leukaemia (CMML) for the presence of this mutation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-10706069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-114472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-14452118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1527326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1699718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1708916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1711568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1712644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1712701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1715789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1750431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-1951328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-2002248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-2128807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-2448137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-2456920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-2582403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-3054417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-3131594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-3409177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-3543899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-3860469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-6614308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-6632719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-7479840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-7530509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-7531822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-7678090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-7691885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-7694008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-8418407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-8589724,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-9378823,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-9600817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-9737247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-9827716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-9829852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-9858225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11040941-9990072
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1366-8714
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
188-93
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11040941-Aged,
pubmed-meshheading:11040941-Bone Marrow Cells,
pubmed-meshheading:11040941-DNA, Neoplasm,
pubmed-meshheading:11040941-Humans,
pubmed-meshheading:11040941-Leukemia, Myelomonocytic, Chronic,
pubmed-meshheading:11040941-Male,
pubmed-meshheading:11040941-Mastocytosis,
pubmed-meshheading:11040941-Neoplasm Proteins,
pubmed-meshheading:11040941-Point Mutation,
pubmed-meshheading:11040941-Proto-Oncogene Proteins c-kit
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pubmed:year |
2000
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pubmed:articleTitle |
Detection of c-kit mutation Asp 816 to Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with chronic myelomonocytic leukaemia.
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pubmed:affiliation |
Institute of Pathology, University Hospital Tübingen, Germany.
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pubmed:publicationType |
Journal Article,
Case Reports
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