Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-12-6
pubmed:abstractText
Primary open-angle glaucoma, the most common form of glaucoma is a slowly progressive atrophy of the optic nerve, characterized by loss of peripheral visual function and is usually associated with elevated intraocular pressure. The etiology and genetic risk factors of primary open-angle glaucoma are mostly unknown. The aim of this study was to find out whether the polymorphism at GSTM1, GSTM3, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma, because these polymorphic enzymes are susceptibility candidates for several diseases, including such eye disease as cataract. The phenotype of GSTM1 and GSTT1 was determined by ELISA and the genotype of GSTM3 and GSTP1 was detected by polymerase chain reaction. Four hundred and fifty two Estonians (250 glaucomas and 202 controls) participated in a case-control study. A significant association of the GSTM1 polymorphism with glaucoma was observed. The frequency of the GSTM1 positive individuals among the glaucoma group was significantly higher than in controls (60 vs. 45.0%) with odds ratio of 1.83 (95% CI 1.26-2.66;P = 0.002). The risk among the GSTM1 positive individuals of developing glaucoma was even higher in the case of smoking: 62.7% of smokers were GSTM1 positive in the glaucoma group while only 33.3% of smokers had GSTM1 positive phenotype in controls (OR = 3.36; 95% CI 1.49-7.56;P = 0.012). An association with a lower level of significance was also found with the GSTM3 gene. Four% of the 250 patients with POAG were identified as carriers of the GSTM3 BB genotype, a proportion which was slightly higher than the 1.0% for the controls (OR = 4.17; 95% CI 0. 90-19.24;P = 0.144). The frequencies of the GSTT1 and GSTP1 genotypes in both groups were not statistically different. The present study suggests that the GSTM1 polymorphism may be associated with increased risk of development of primary open-angle glaucoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-4835
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Academic Press.
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
447-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11040079-Adult, pubmed-meshheading:11040079-Aged, pubmed-meshheading:11040079-Aged, 80 and over, pubmed-meshheading:11040079-Case-Control Studies, pubmed-meshheading:11040079-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:11040079-Female, pubmed-meshheading:11040079-Genetic Predisposition to Disease, pubmed-meshheading:11040079-Genotype, pubmed-meshheading:11040079-Glaucoma, Open-Angle, pubmed-meshheading:11040079-Glutathione Transferase, pubmed-meshheading:11040079-Humans, pubmed-meshheading:11040079-Male, pubmed-meshheading:11040079-Middle Aged, pubmed-meshheading:11040079-Odds Ratio, pubmed-meshheading:11040079-Phenotype, pubmed-meshheading:11040079-Polymerase Chain Reaction, pubmed-meshheading:11040079-Polymorphism, Genetic, pubmed-meshheading:11040079-Risk Factors, pubmed-meshheading:11040079-Smoking
pubmed:year
2000
pubmed:articleTitle
Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians.
pubmed:affiliation
Department of Human Biology and Genetics, Institute of General and Molecular Pathology, Estonia. ejuronen@ut.ee
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't