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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
42
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pubmed:dateCreated |
2000-11-9
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pubmed:abstractText |
In A549 human lung adenocarcinoma cells, we found that TNF-alpha and several commonly used chemotherapeutic agents upregulated the expression of Bcl-x and/or Bfl-1/A1 through an NF-kappaB-dependent pathway. While parental A549 cells were resistant to the cytotoxic effects of both TNF-alpha and chemotherapy agents, NF-kappaB-blocked A549 cells were sensitized to both. Expression of either Bcl-x or Bfl-1/A1 in the NF-kappaB-deficient cells at physiological levels provided differential protection against TNF-alpha and chemotherapeutic treatment. These studies provide a potential mechanism for the phenomenon of chemotherapy-induced chemoresistance, and also reveal a potential strategy by which chemoresistance can be overcome.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/BCL2-related protein A1,
http://linkedlifedata.com/resource/pubmed/chemical/BCL2L1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Doxycycline,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-X Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4936-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11039911-Adenocarcinoma,
pubmed-meshheading:11039911-Antineoplastic Agents,
pubmed-meshheading:11039911-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:11039911-DNA-Binding Proteins,
pubmed-meshheading:11039911-Doxycycline,
pubmed-meshheading:11039911-Drug Resistance, Neoplasm,
pubmed-meshheading:11039911-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11039911-Humans,
pubmed-meshheading:11039911-I-kappa B Proteins,
pubmed-meshheading:11039911-Lung Neoplasms,
pubmed-meshheading:11039911-NF-kappa B,
pubmed-meshheading:11039911-Neoplasm Proteins,
pubmed-meshheading:11039911-Protein Biosynthesis,
pubmed-meshheading:11039911-Proteins,
pubmed-meshheading:11039911-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11039911-RNA, Messenger,
pubmed-meshheading:11039911-RNA, Neoplasm,
pubmed-meshheading:11039911-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:11039911-Recombinant Fusion Proteins,
pubmed-meshheading:11039911-Transfection,
pubmed-meshheading:11039911-Tumor Cells, Cultured,
pubmed-meshheading:11039911-Tumor Necrosis Factor-alpha,
pubmed-meshheading:11039911-bcl-X Protein
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pubmed:year |
2000
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pubmed:articleTitle |
Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-kappaB inhibition.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, University of California Los Angeles, 90095, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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