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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
42
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pubmed:dateCreated |
2000-11-9
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pubmed:abstractText |
MYC transcription factors are potent stimulators of cell proliferation. It has been suggested that the CDK-inhibitor p27kip1 is a critical G1 phase cell cycle target of c-MYC. We show here that mouse embryo fibroblasts deficient for both p27kip1 and the related p21cip1 are still responsive to stimulation by c-MYC and can be arrested in G1 by a dominant negative mutant of c-MYC. This growth arrest can be overruled by ectopic expression of E2F or adenovirus E1A, but not by a mutant of E1A defective for binding to retinoblastoma family proteins. We show that fibroblasts with a genetic disruption of all three retinoblastoma family members (pRb, p107 and p130) are unresponsive to a dominant negative c-MYC mutant. These data indicate that p27kip1 is not the only rate limiting cell cycle target of c-MYC and suggest that regulation of E2F is also essential for c-MYC's mitogenic activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenovirus E1A Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Arid4a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn1b protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E2F Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/Rbl1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Rbl2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Binding Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Like Protein p107,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma-Like Protein p130,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor DP1,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0950-9232
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4822-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11039898-Adenovirus E1A Proteins,
pubmed-meshheading:11039898-Animals,
pubmed-meshheading:11039898-Carrier Proteins,
pubmed-meshheading:11039898-Cell Cycle,
pubmed-meshheading:11039898-Cell Cycle Proteins,
pubmed-meshheading:11039898-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:11039898-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:11039898-Cyclins,
pubmed-meshheading:11039898-DNA-Binding Proteins,
pubmed-meshheading:11039898-E2F Transcription Factors,
pubmed-meshheading:11039898-Fibroblasts,
pubmed-meshheading:11039898-G1 Phase,
pubmed-meshheading:11039898-Genes, Dominant,
pubmed-meshheading:11039898-Genes, Retinoblastoma,
pubmed-meshheading:11039898-Genes, cdc,
pubmed-meshheading:11039898-Genes, myc,
pubmed-meshheading:11039898-Mice,
pubmed-meshheading:11039898-Mice, Knockout,
pubmed-meshheading:11039898-Microtubule-Associated Proteins,
pubmed-meshheading:11039898-Nuclear Proteins,
pubmed-meshheading:11039898-Phosphoproteins,
pubmed-meshheading:11039898-Proteins,
pubmed-meshheading:11039898-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:11039898-Recombinant Fusion Proteins,
pubmed-meshheading:11039898-Retinoblastoma Protein,
pubmed-meshheading:11039898-Retinoblastoma-Binding Protein 1,
pubmed-meshheading:11039898-Retinoblastoma-Like Protein p107,
pubmed-meshheading:11039898-Retinoblastoma-Like Protein p130,
pubmed-meshheading:11039898-S Phase,
pubmed-meshheading:11039898-Transcription Factor DP1,
pubmed-meshheading:11039898-Transcription Factors,
pubmed-meshheading:11039898-Tumor Suppressor Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
p27kip1-independent cell cycle regulation by MYC.
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pubmed:affiliation |
Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands' Cancer Institute, Amsterdam.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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