Source:http://linkedlifedata.com/resource/pubmed/id/11039130
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2001-1-23
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| pubmed:abstractText |
Intensive multimodality treatment has led to a remarkable improvement of prognosis in paediatric cancer patients, however, a great number of long-term survivors suffer from considerable tumour- or treatment-related late effects. Between January 1990 and December 1998, 223 consecutive survivors of childhood malignancies entered a prospective follow-up study designed to evaluate the frequency and severity of tumour- and/or therapy-related long-term sequelae. After cessation of therapy and subsequently once a year, all patients underwent a detailed examination programme including physical examination, laboratory tests, abdominal sonography, echocardiography, electrocardiography, electroencephalography, spirometry, audiometry, ophthalmological examination and endocrine stimulation tests. Median follow-up was 5 years (range 0.4 to 9.6 years). A total of 167 patients (75%) had at least one chronic medical problem of whom 80 needed permanent medical support. The organ systems most frequently affected were the nervous system in 39%, the endocrine system in 32%, the ears/eyes in 22%, the kidneys in 17%, and the liver in 12% of the patients. Some late effects (endocrine deficits, hearing loss, tubulopathy) were primarily diagnosed only several years after the end of oncological therapy. CONCLUSION: The results of this study indicate that a considerable number of former paediatric cancer patients suffer from remarkable long-term side-effects. Since life quality is an important parameter of cancer survival, careful follow-up of long-term survivors is mandatory with the aim to reduce or even abrogate possible side-effects at the earliest time.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
0340-6199
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
159
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
750-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11039130-Adolescent,
pubmed-meshheading:11039130-Adult,
pubmed-meshheading:11039130-Austria,
pubmed-meshheading:11039130-Child,
pubmed-meshheading:11039130-Chronic Disease,
pubmed-meshheading:11039130-Combined Modality Therapy,
pubmed-meshheading:11039130-Female,
pubmed-meshheading:11039130-Follow-Up Studies,
pubmed-meshheading:11039130-Humans,
pubmed-meshheading:11039130-Infant,
pubmed-meshheading:11039130-Male,
pubmed-meshheading:11039130-Neoplasms,
pubmed-meshheading:11039130-Outcome Assessment (Health Care),
pubmed-meshheading:11039130-Prospective Studies,
pubmed-meshheading:11039130-Quality of Life,
pubmed-meshheading:11039130-Rehabilitation,
pubmed-meshheading:11039130-Severity of Illness Index,
pubmed-meshheading:11039130-Surgical Procedures, Operative,
pubmed-meshheading:11039130-Survivors
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Prospective evaluation of late effects after childhood cancer therapy with a follow-up over 9 years.
|
| pubmed:affiliation |
Department of Paediatrics, University of Graz, Austria. herwig.lackner@kfunigraz.ac.at
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| pubmed:publicationType |
Journal Article
|