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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0002844,
umls-concept:C0009013,
umls-concept:C0030551,
umls-concept:C0178539,
umls-concept:C0205263,
umls-concept:C0332197,
umls-concept:C0334227,
umls-concept:C0376358,
umls-concept:C0580822,
umls-concept:C0871161,
umls-concept:C0871712,
umls-concept:C1521991,
umls-concept:C1547300,
umls-concept:C1548760,
umls-concept:C1549059,
umls-concept:C1550594
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pubmed:issue |
4
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pubmed:dateCreated |
2001-1-16
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pubmed:abstractText |
The mechanism of progression of human prostate cancer (CaP) cells under androgen ablation therapy remains unclear. To study the alternative pathways of CaP cell growth under conditions of androgen deprivation, androgen-independent CaP variants were selected and expanded from an androgen-dependent CaP line via an in vitro androgen deprivation treatment. Cellular and molecular properties of these androgen-independent variants were characterized both in vitro and in vivo and compared with those of their parental androgen-dependent cells.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:issn |
1528-9117
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pubmed:author |
pubmed-author:BelldegrunAA,
pubmed-author:CaliliwRR,
pubmed-author:GitlitzBB,
pubmed-author:McBrideW HWH,
pubmed-author:PaikS HSH,
pubmed-author:PatelBB,
pubmed-author:SunJJ,
pubmed-author:TsoC LCL,
pubmed-author:TsuiK HKH,
pubmed-author:WuLL,
pubmed-author:deKernionJJ,
pubmed-author:van OphovenAA
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
220-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11038142-Androgens,
pubmed-meshheading:11038142-Animals,
pubmed-meshheading:11038142-Bone Marrow Cells,
pubmed-meshheading:11038142-Cell Culture Techniques,
pubmed-meshheading:11038142-Cell Division,
pubmed-meshheading:11038142-Cells, Cultured,
pubmed-meshheading:11038142-Clone Cells,
pubmed-meshheading:11038142-DNA, Neoplasm,
pubmed-meshheading:11038142-Drug Resistance, Neoplasm,
pubmed-meshheading:11038142-Endothelium,
pubmed-meshheading:11038142-Female,
pubmed-meshheading:11038142-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11038142-Humans,
pubmed-meshheading:11038142-Male,
pubmed-meshheading:11038142-Mice,
pubmed-meshheading:11038142-Mice, SCID,
pubmed-meshheading:11038142-Neoplasm Invasiveness,
pubmed-meshheading:11038142-Neoplasm Metastasis,
pubmed-meshheading:11038142-Neoplasms, Hormone-Dependent,
pubmed-meshheading:11038142-Phenotype,
pubmed-meshheading:11038142-Prostatic Neoplasms,
pubmed-meshheading:11038142-Stromal Cells,
pubmed-meshheading:11038142-Transcription, Genetic,
pubmed-meshheading:11038142-Tumor Cells, Cultured
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pubmed:articleTitle |
Androgen deprivation induces selective outgrowth of aggressive hormone-refractory prostate cancer clones expressing distinct cellular and molecular properties not present in parental androgen-dependent cancer cells.
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pubmed:affiliation |
Department of Urology, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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