|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2001-1-9
|
|
pubmed:abstractText |
Vascular endothelial growth factor is an angiogenic peptide that binds to tyrosine kinase receptors on target cells to activate signal transduction pathways involving phosphatidylinositol 3'-kinase and the serine-threonine protein kinase, Akt. To determine whether this signaling pathway is activated in cerebral ischemia, we examined the expression of vascular endothelial growth factor receptors 1 and 2, and phosphatidylinositol 3'-kinase-activated phospho-Akt, in the cerebral cortex and hippocampus following transient global cerebral ischemia in the rat. Western blot analysis and immunocytochemistry demonstrated induction of vascular endothelial growth factor receptor 1 and 2 expression, and of anti-phosphatidylinositol 3'-kinase-immunoprecipitated phospho-Akt, in vulnerable regions of the cortex and hippocampus after 15 min of global ischemia and 4-72 h of reperfusion. These findings demonstrate that vascular endothelial growth factor receptors and receptor-coupled signal transduction pathways are induced in ischemic brain in vivo, and could therefore participate in endogenous neuroprotective responses to ischemia.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Akt1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0306-4522
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
100
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
713-7
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11036205-Animals,
pubmed-meshheading:11036205-Blotting, Western,
pubmed-meshheading:11036205-Cerebral Cortex,
pubmed-meshheading:11036205-Hippocampus,
pubmed-meshheading:11036205-Immunohistochemistry,
pubmed-meshheading:11036205-Ischemic Attack, Transient,
pubmed-meshheading:11036205-Male,
pubmed-meshheading:11036205-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:11036205-Phosphorylation,
pubmed-meshheading:11036205-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11036205-Proto-Oncogene Proteins,
pubmed-meshheading:11036205-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:11036205-Rats,
pubmed-meshheading:11036205-Rats, Sprague-Dawley,
pubmed-meshheading:11036205-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:11036205-Receptors, Growth Factor,
pubmed-meshheading:11036205-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:11036205-Signal Transduction
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3'-kinase/Akt signaling by global cerebral ischemia in the rat.
|
|
pubmed:affiliation |
Buck Center for Research in Aging, PO Box 638, CA 94948-0638, Novato, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
