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pubmed-article:11036113pubmed:abstractTextThe cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5' promoter region of the CYP17 gene. Because steroid hormone exposure is known to influence breast cancer risk, we conducted a population-based, case-control-family study to assess the relationship between the CYP17 promoter polymorphism and early-onset breast cancer.lld:pubmed
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pubmed-article:11036113pubmed:articleTitleCYP17 promoter polymorphism and breast cancer in Australian women under age forty years.lld:pubmed
pubmed-article:11036113pubmed:affiliationCancer Unit, Joint Experimental Oncology Programme, The Queensland Institute of Medical Research, and The University of Queensland, Brisbane, Australia. mandyS@qimr.edu.aulld:pubmed
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