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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2000-10-30
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pubmed:abstractText |
The cytochrome P450c17alpha enzyme functions in the steroid biosynthesis pathway, and altered endogenous steroid hormone levels have been reported to be associated with a T to C polymorphism in the 5' promoter region of the CYP17 gene. Because steroid hormone exposure is known to influence breast cancer risk, we conducted a population-based, case-control-family study to assess the relationship between the CYP17 promoter polymorphism and early-onset breast cancer.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8874
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pubmed:author |
pubmed-author:Chenevix-TrenchGG,
pubmed-author:ChewAA,
pubmed-author:CukDD,
pubmed-author:DiteG SGS,
pubmed-author:EastonD FDF,
pubmed-author:GilesG GGG,
pubmed-author:HopperJ LJL,
pubmed-author:McCredieM RMR,
pubmed-author:SoutheyM CMC,
pubmed-author:SpurdleA BAB,
pubmed-author:VenterD JDJ
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1674-81
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11036113-Adult,
pubmed-meshheading:11036113-Age Factors,
pubmed-meshheading:11036113-Age of Onset,
pubmed-meshheading:11036113-Alleles,
pubmed-meshheading:11036113-Australia,
pubmed-meshheading:11036113-Breast Neoplasms,
pubmed-meshheading:11036113-Case-Control Studies,
pubmed-meshheading:11036113-DNA, Neoplasm,
pubmed-meshheading:11036113-DNA Primers,
pubmed-meshheading:11036113-Female,
pubmed-meshheading:11036113-Genes, BRCA1,
pubmed-meshheading:11036113-Genes, Tumor Suppressor,
pubmed-meshheading:11036113-Genotype,
pubmed-meshheading:11036113-Humans,
pubmed-meshheading:11036113-Logistic Models,
pubmed-meshheading:11036113-Mutation,
pubmed-meshheading:11036113-Polymerase Chain Reaction,
pubmed-meshheading:11036113-Polymorphism, Genetic,
pubmed-meshheading:11036113-Promoter Regions, Genetic,
pubmed-meshheading:11036113-Risk,
pubmed-meshheading:11036113-Steroid 17-alpha-Hydroxylase
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pubmed:year |
2000
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pubmed:articleTitle |
CYP17 promoter polymorphism and breast cancer in Australian women under age forty years.
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pubmed:affiliation |
Cancer Unit, Joint Experimental Oncology Programme, The Queensland Institute of Medical Research, and The University of Queensland, Brisbane, Australia. mandyS@qimr.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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