Source:http://linkedlifedata.com/resource/pubmed/id/11035668
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2000-11-2
|
| pubmed:abstractText |
There is no agreement about the efficacy of systemic corticosteroids in patients with COPD, but corticosteroids often are employed during exacerbations of the disease. The use of systemic or inhaled corticosteroids in patients in stable condition is even more controversial, even though the more severely affected patients seem to respond better. Unfortunately, in this subset of patients, the use of forced expiratory maneuvers frequently fails to detect significant functional response. Study objectives: We evaluated the short-term effects of an inhaled corticosteroid, fluticasone propionate (FP), on FEV(1) and on the mechanical properties of patients in stable condition with severe COPD and chronic hypercapnic respiratory failure who were receiving long-term ventilatory support. This allowed us to measure respiratory mechanics (RM) passively, thereby avoiding any problems linked with voluntary maneuvers.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0012-3692
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
118
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
990-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11035668-Administration, Inhalation,
pubmed-meshheading:11035668-Administration, Topical,
pubmed-meshheading:11035668-Adult,
pubmed-meshheading:11035668-Aged,
pubmed-meshheading:11035668-Airway Resistance,
pubmed-meshheading:11035668-Androstadienes,
pubmed-meshheading:11035668-Anti-Inflammatory Agents,
pubmed-meshheading:11035668-Blood Gas Analysis,
pubmed-meshheading:11035668-Cross-Over Studies,
pubmed-meshheading:11035668-Double-Blind Method,
pubmed-meshheading:11035668-Female,
pubmed-meshheading:11035668-Forced Expiratory Volume,
pubmed-meshheading:11035668-Glucocorticoids,
pubmed-meshheading:11035668-Humans,
pubmed-meshheading:11035668-Lung Compliance,
pubmed-meshheading:11035668-Lung Diseases, Obstructive,
pubmed-meshheading:11035668-Male,
pubmed-meshheading:11035668-Middle Aged,
pubmed-meshheading:11035668-Nebulizers and Vaporizers,
pubmed-meshheading:11035668-Positive-Pressure Respiration,
pubmed-meshheading:11035668-Treatment Outcome
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Controlled short-term trial of fluticasone propionate in ventilator-dependent patients with COPD.
|
| pubmed:affiliation |
Respiratory Intensive Care Unit, Fondazione S. Mougeri, Istituto Scientifico di Pavia, FRCCS, Pavia, Italy. snava@fsm.it
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|