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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2000-10-19
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pubmed:abstractText |
The major platelet integrin glycoprotein IIb-IIIa plays a primary role in platelet aggregation and acute thrombus formation at the site of vascular injury. A genetic polymorphism of glycoprotein IIb-IIIa (Pl(A)) has recently been proposed as a potential genetic factor linking to platelet hyperaggregability and increased risk of myocardial infarction. Despite numerous, mostly nonprospective studies, the role of this polymorphism as a clinically relevant, inherited risk factor for coronary heart disease (CHD) is still controversial. The purpose of this study was to determine whether Pl(A2) is a risk factor for incident CHD and whether it is correlated with increased platelet activation in a case-cohort study nested within a prospective epidemiologic investigation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
17
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1901-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11034936-Alleles,
pubmed-meshheading:11034936-Antigens, Human Platelet,
pubmed-meshheading:11034936-Case-Control Studies,
pubmed-meshheading:11034936-Cohort Studies,
pubmed-meshheading:11034936-Coronary Disease,
pubmed-meshheading:11034936-Female,
pubmed-meshheading:11034936-Gene Frequency,
pubmed-meshheading:11034936-Genotype,
pubmed-meshheading:11034936-Humans,
pubmed-meshheading:11034936-Incidence,
pubmed-meshheading:11034936-Male,
pubmed-meshheading:11034936-Middle Aged,
pubmed-meshheading:11034936-Platelet Activation,
pubmed-meshheading:11034936-Polymerase Chain Reaction,
pubmed-meshheading:11034936-Polymorphism, Genetic,
pubmed-meshheading:11034936-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:11034936-Prospective Studies,
pubmed-meshheading:11034936-Regression Analysis,
pubmed-meshheading:11034936-Risk Factors,
pubmed-meshheading:11034936-Seroepidemiologic Studies,
pubmed-meshheading:11034936-beta-Thromboglobulin
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pubmed:year |
2000
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pubmed:articleTitle |
Platelet Pl(A2) allele and incidence of coronary heart disease: results from the Atherosclerosis Risk In Communities (ARIC) Study.
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pubmed:affiliation |
Division of Hematology and Vascular Biology Research Center, University of Texas-Houston Medical School, Houston, TX 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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