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rdf:type |
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lifeskim:mentions |
umls-concept:C0018894,
umls-concept:C0021764,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0079189,
umls-concept:C0085295,
umls-concept:C0205195,
umls-concept:C0205263,
umls-concept:C0449475,
umls-concept:C1948023,
umls-concept:C2246411
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pubmed:issue |
8
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pubmed:dateCreated |
2000-11-9
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pubmed:abstractText |
Mast cells are found in connective and mucosal tissues throughout the body. Their activation via immunoglobulin E (IgE)-antigen interactions is promoted by T helper cell type 2 (Th2) cytokines and leads to the sequelae of allergic disease. We now report a mechanism by which Th2 cytokines can regulate mast cell survival. Specifically, we find that interleukin (IL)-4 and IL-10 induce apoptosis in IL-3-dependent bone marrow-derived mast cells and peritoneal mast cells. This process required 6 d of costimulation with IL-3, IL-4, and IL-10, and expression of signal transducer and activator of transcription 6 (Stat6). Apoptosis was coupled with decreased expression of bcl-x(L) and bcl-2. While this process occurred independent of the Fas pathway, culture in IL-3+IL-4+IL-10 greatly sensitized mast cells to Fas-mediated death. Additionally, we found that IgE cross-linkage or stimulation with stem cell factor enhanced the apoptotic abilities of IL-4 and IL-10. Finally, IL-3-independent mastocytomas and mast cell lines were resistant to apoptosis induced by IL-3+IL-4+IL-10. These data offer evidence of Th2 cytokine-mediated homeostasis whereby these cytokines both elicit and limit allergic responses. Dysregulation of this pathway may play a role in allergic disease and mast cell tumor survival.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-10233740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-10358772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-10452990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-10528217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-1541822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-1899106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-2018830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-3090545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-315919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-3170991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-3491870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-7479840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-7513208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-7528573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-7535336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-7579337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-7687619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-7722292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-8068938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-8142640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-8247150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-8546223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-8962111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9000580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9366408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9378990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9492006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9735050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9751635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9767446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9794832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9847443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11034599-9862725
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
192
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1093-103
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11034599-Animals,
pubmed-meshheading:11034599-Annexin A5,
pubmed-meshheading:11034599-Apoptosis,
pubmed-meshheading:11034599-Bone Marrow Cells,
pubmed-meshheading:11034599-Cells, Cultured,
pubmed-meshheading:11034599-Flow Cytometry,
pubmed-meshheading:11034599-Interleukin-10,
pubmed-meshheading:11034599-Interleukin-3,
pubmed-meshheading:11034599-Interleukin-4,
pubmed-meshheading:11034599-Kinetics,
pubmed-meshheading:11034599-Mast Cells,
pubmed-meshheading:11034599-Mice,
pubmed-meshheading:11034599-Mice, Inbred C57BL,
pubmed-meshheading:11034599-Mice, Inbred Strains,
pubmed-meshheading:11034599-Recombinant Proteins,
pubmed-meshheading:11034599-Stem Cell Factor,
pubmed-meshheading:11034599-Th2 Cells
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pubmed:year |
2000
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pubmed:articleTitle |
Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis.
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pubmed:affiliation |
Department of Biology, Virginia Commonwealth University, Richmond, Virginia 23284, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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