Linked Life Data

11034417

Source:http://linkedlifedata.com/resource/pubmed/id/11034417

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2000-10-16
pubmed:abstractText
Recent evidence suggests that the previously enigmatic cell type designated plasmacytoid monocytes can function as dendritic cells and contribute substantially to both innate and adaptive immunity. This cell type has previously been described only in bone marrow, blood, and organized lymphoid tissue, but not at effector sites with direct Ag exposure such as the mucosae. Plasmacytoid dendritic cells (P-DCs) matured in vitro can induce T cells to produce allergy-promoting Th2 cytokines; therefore, their possible occurrence in nasal mucosa during experimentally elicited allergic rhinitis was examined. Patients with silent nasal allergy were challenged topically with relevant allergen daily for 7 days. Biopsy specimens as well as blood samples were obtained before and during such provocation, and P-DCs were identified by their high expression of CD123 (IL-3R alpha-chain), together with CD45RA. Our results showed that P-DCs were present in low and variable numbers in normal nasal mucosa but increased dramatically during the allergic reaction. This accumulation concurred with the expression of the L-selectin ligand peripheral lymph node addressin on the mucosal vascular endothelium. The latter observation was particularly interesting in view of the high levels of L-selectin on circulating P-DC precursors and of previous reports suggesting that these cells can enter organized lymphoid tissue via high endothelial venules (which express peripheral lymph node addressin constitutively). Together, our findings suggested that P-DCs are involved in the triggering of airway allergy and that they are directed to allergic lesions by adhesion molecules that normally mediate leukocyte extravasation in organized lymphoid tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
165
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4062-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11034417-Administration, Topical, pubmed-meshheading:11034417-Adult, pubmed-meshheading:11034417-Allergens, pubmed-meshheading:11034417-Antigens, CD1, pubmed-meshheading:11034417-Cell Division, pubmed-meshheading:11034417-Cell Movement, pubmed-meshheading:11034417-Dendritic Cells, pubmed-meshheading:11034417-Endothelium, Lymphatic, pubmed-meshheading:11034417-Female, pubmed-meshheading:11034417-GTP-Binding Proteins, pubmed-meshheading:11034417-Hematopoietic Stem Cells, pubmed-meshheading:11034417-Humans, pubmed-meshheading:11034417-Hypersensitivity, Immediate, pubmed-meshheading:11034417-Immunoglobulins, pubmed-meshheading:11034417-Immunophenotyping, pubmed-meshheading:11034417-Male, pubmed-meshheading:11034417-Mucoproteins, pubmed-meshheading:11034417-Nasal Mucosa, pubmed-meshheading:11034417-Palatine Tonsil, pubmed-meshheading:11034417-Plasma Cells, pubmed-meshheading:11034417-Protein Biosynthesis, pubmed-meshheading:11034417-Receptors, IgE
pubmed:year
2000
pubmed:articleTitle
Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy.
pubmed:affiliation
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, Norway.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't