Linked Life Data

11033010

Source:http://linkedlifedata.com/resource/pubmed/id/11033010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2000-12-21
pubmed:abstractText
The majority of adult nucleus accumbens medium spiny neurons exhibit a bistable membrane potential that fluctuates between a relatively hyperpolarized (Down) state (average=-76 mV) and a less hyperpolarized (Up) state (average=-60 mV) near firing threshold. During in vivo extracellular recordings from nucleus accumbens neurons, we used microiontophoresis to apply glutamate and selected neurons that fired in bursting patterns reflecting a subthreshold bistable membrane potential. The average frequency of bursts events was 0.85 Hz. The average burst duration was 392+/-3.5 ms, with an average of 13.4 spikes and an average spike frequency of 30.6+/-3.1 Hz per burst. To determine the involvement of the L-type calcium channel in the bursting pattern, we applied the benzothiazepine L-type calcium channel blocker, diltiazem. Diltiazem rapidly (<2 min) and reversibly decreased the burst duration by 29% and the frequency of spikes within a burst by 30% without changing the overall burst event frequency. The results provide the first in vivo electrophysiological evidence implicating an L-type calcium channel that modulates glutamate-induced burst firing of nucleus accumbens neurons.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
880
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
212-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
L-type calcium channels modulate glutamate-driven bursting activity in the nucleus accumbens in vivo.
pubmed:affiliation
Department of Neuroscience, Finch University of Health Sciences, The Chicago Medical School, 3333 Green Bay Rd, North Chicago, IL 60064, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.