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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
7
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pubmed:dateCreated |
2000-12-5
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|
pubmed:abstractText |
Recent brain imaging studies have indicated that schizophrenia is associated with increased amphetamine-induced dopamine release in the striatum. It has long been hypothesized that dysregulation of subcortical dopamine systems in schizophrenia might result from a failure of the prefrontal cortex (PFC) to adequately control subcortical dopaminergic function. The activity of midbrain dopaminergic neurons is regulated, in part, by glutamatergic projections from the PFC acting via glutamatergic N-methyl-D-aspartate (NMDA) receptors. The goal of this study was to test the hypothesis that a pharmacologically induced disruption of NMDA transmission leads to an increase in amphetamine-induced dopamine release in humans.
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pubmed:grant |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-3223
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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|
pubmed:volume |
48
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
627-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11032974-Adult,
pubmed-meshheading:11032974-Amphetamine,
pubmed-meshheading:11032974-Benzamides,
pubmed-meshheading:11032974-Corpus Striatum,
pubmed-meshheading:11032974-Dopamine,
pubmed-meshheading:11032974-Dopamine Agents,
pubmed-meshheading:11032974-Dopamine Antagonists,
pubmed-meshheading:11032974-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11032974-Female,
pubmed-meshheading:11032974-Humans,
pubmed-meshheading:11032974-Ketamine,
pubmed-meshheading:11032974-Male,
pubmed-meshheading:11032974-Prefrontal Cortex,
pubmed-meshheading:11032974-Pyrrolidines,
pubmed-meshheading:11032974-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:11032974-Schizophrenia,
pubmed-meshheading:11032974-Synaptic Transmission,
pubmed-meshheading:11032974-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2000
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|
pubmed:articleTitle |
Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia.
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pubmed:affiliation |
Department of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.
|
