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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-1-4
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF122013,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283327,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283328,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283329,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283330,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283331,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283332,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283333,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283334,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283335,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283336,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283337,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283338,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283339,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283340,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283341,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283342,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283343,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283344,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283345,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283346,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283347,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283348,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283349,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283350,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283351,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283352,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283353,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283354,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AF283355
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pubmed:abstractText |
LRP1B is a novel candidate tumor suppressor gene that is inactivated by genetic and transcript alterations in nearly 50% of non-small-cell lung cancer cell lines. The gene-encoded protein is highly homologous to the gigantic lipoprotein receptor-related protein 1 (LRP1) that belongs to the family of low-density lipoprotein receptors. Using a combination of PCR-based genome walking and long-distance interexon PCR, we have determined the genomic organization of LRP1B and built a contiguous array of BAC clones spanning this gene. A total of 91 exons, varying in size from 77 bases (exon 87) to 1899 bases (exon 91), were identified in the more than 500-kb-long gene sequence. Comparative analysis of the genomic structures of LRP1B and the homologous LRP1 gene revealed a striking similarity in the location and sizes of their exons.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11031110-Chromosomes, Artificial, Bacterial,
pubmed-meshheading:11031110-Exons,
pubmed-meshheading:11031110-Genes, Tumor Suppressor,
pubmed-meshheading:11031110-Humans,
pubmed-meshheading:11031110-Introns,
pubmed-meshheading:11031110-Low Density Lipoprotein Receptor-Related Protein-1,
pubmed-meshheading:11031110-Molecular Sequence Data,
pubmed-meshheading:11031110-Receptors, Immunologic,
pubmed-meshheading:11031110-Sequence Homology, Nucleic Acid
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pubmed:year |
2000
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pubmed:articleTitle |
Genomic organization of a new candidate tumor suppressor gene, LRP1B.
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pubmed:affiliation |
Laboratory of Cancer Genetics, Department of Genetics, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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