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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-11-3
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pubmed:abstractText |
We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The germline-intrinsic group, defined as genes expressed similarly in germlines making only sperm or only oocytes, contains a family of piwi-related genes that may be important for stem cell proliferation. Finally, examination of the chromosomal location of germline transcripts revealed that sperm-enriched and germline-intrinsic genes are nearly absent from the X chromosome, but oocyte-enriched genes are not.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Argonaute Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FEM-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Helminth Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mom-5 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/PRG-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/PRG-2 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Induced Silencing Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/WRM-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/fem-3 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/mom-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/piwi protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-2765
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pubmed:author |
pubmed-author:BegleyRR,
pubmed-author:DavisE BEB,
pubmed-author:JonesS JSJ,
pubmed-author:KimS KSK,
pubmed-author:NanceJJ,
pubmed-author:ReinkeVV,
pubmed-author:SchererSS,
pubmed-author:SmithH EHE,
pubmed-author:Van DorenCC,
pubmed-author:WangJJ,
pubmed-author:WardSS
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-16
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11030340-Animals,
pubmed-meshheading:11030340-Argonaute Proteins,
pubmed-meshheading:11030340-Caenorhabditis elegans,
pubmed-meshheading:11030340-Caenorhabditis elegans Proteins,
pubmed-meshheading:11030340-Cell Cycle Proteins,
pubmed-meshheading:11030340-Cytoskeletal Proteins,
pubmed-meshheading:11030340-Drosophila Proteins,
pubmed-meshheading:11030340-Gene Expression Profiling,
pubmed-meshheading:11030340-Gene Expression Regulation, Developmental,
pubmed-meshheading:11030340-Helminth Proteins,
pubmed-meshheading:11030340-Male,
pubmed-meshheading:11030340-Membrane Proteins,
pubmed-meshheading:11030340-Oocytes,
pubmed-meshheading:11030340-Proteins,
pubmed-meshheading:11030340-RNA, Messenger,
pubmed-meshheading:11030340-RNA-Induced Silencing Complex,
pubmed-meshheading:11030340-Receptors, Notch,
pubmed-meshheading:11030340-Spermatogenesis,
pubmed-meshheading:11030340-Spermatozoa,
pubmed-meshheading:11030340-X Chromosome
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pubmed:year |
2000
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pubmed:articleTitle |
A global profile of germline gene expression in C. elegans.
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pubmed:affiliation |
Department of Developmental Biology, Stanford University School of Medicine, California 94305, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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