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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0026336,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205234,
umls-concept:C0205263,
umls-concept:C0205314,
umls-concept:C0205421,
umls-concept:C0206256,
umls-concept:C0679622,
umls-concept:C0917798
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pubmed:issue |
10
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pubmed:dateCreated |
2000-11-3
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pubmed:abstractText |
This study aimed at evaluating changes in expression of immediate early genes in a new photothrombotic focal ischemia model that exhibits late spontaneous reperfusion and morphological restoration in the region-at-risk within the cerebral cortex. Gene expression was studied with Northern blots, in situ hybridization and immunohistochemistry. At early time points (1-4 h), nerve growth factor-induced gene A and B, and c-fos mRNAs, were quickly induced throughout the ipsilateral cortex, with no obvious differences between the region-at-risk and remote cortical areas. High concentrations of nerve growth factor-induced gene A and c-Fos proteins were present within the region-at-risk even when cortical cerebral blood flow was as low as 40% of control values. At 4 h the nerve growth factor-induced gene A mRNA and protein expression was significantly decreased in the hippocampus vs. naive controls. However, a small decrease was also found in sham-operated and anaesthetized controls. A late induction, at 5 days, of c-fos and nerve growth factor-induced gene B mRNAs was seen bilaterally in the hippocampus and also, in the case of nerve growth factor induced-gene B, in the contralateral cortex. A complex pattern of changes in immediate early gene expression occurs after reversible focal cortical ischemia. This may be important for tissue recovery as well as neuropsychiatric symptoms after stroke.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Egr1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nr4a1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 4...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-fos,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Steroid,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0953-816X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3615-25
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11029632-Animals,
pubmed-meshheading:11029632-Brain Ischemia,
pubmed-meshheading:11029632-Cerebral Cortex,
pubmed-meshheading:11029632-DNA-Binding Proteins,
pubmed-meshheading:11029632-Disease Models, Animal,
pubmed-meshheading:11029632-Early Growth Response Protein 1,
pubmed-meshheading:11029632-Gene Expression Regulation,
pubmed-meshheading:11029632-Genes, Immediate-Early,
pubmed-meshheading:11029632-Hippocampus,
pubmed-meshheading:11029632-Immediate-Early Proteins,
pubmed-meshheading:11029632-Male,
pubmed-meshheading:11029632-Neurons,
pubmed-meshheading:11029632-Nuclear Receptor Subfamily 4, Group A, Member 1,
pubmed-meshheading:11029632-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:11029632-RNA, Messenger,
pubmed-meshheading:11029632-Rats,
pubmed-meshheading:11029632-Rats, Wistar,
pubmed-meshheading:11029632-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:11029632-Receptors, Steroid,
pubmed-meshheading:11029632-Time Factors,
pubmed-meshheading:11029632-Transcription Factors
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pubmed:year |
2000
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pubmed:articleTitle |
Early and delayed induction of immediate early gene expression in a novel focal cerebral ischemia model in the rat.
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pubmed:affiliation |
Department of Public Health and Clinical Medicine, Medicine, Umeâ University Hospital, SE-901 85 Umeâ, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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