Source:http://linkedlifedata.com/resource/pubmed/id/11029336
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Pt 1
|
| pubmed:dateCreated |
2000-11-15
|
| pubmed:abstractText |
This study aimed at documenting airway inflammation and subepithelial collagen deposition in patients using only inhaled beta(2)-agonists with either recently diagnosed asthma (RDA: </= 2 yr, n = 16) or long-standing asthma (LSA: >/= 13 yr, n = 16) and at the influence of an intense inhaled corticosteroid (ICS) treatment on these parameters, in relation to changes in airway responsiveness. Patients had a methacholine inhalation test and a bronchoscopy with bronchial biopsies before and after an 8-wk treatment with inhaled fluticasone propionate (FP), 1,000 microgram/day. Baseline FEV(1) (mean +/- SEM) was normal and similar in both groups (RDA: 98.1 +/- 2.7, LSA: 94.5 +/- 4.6%). Geometric mean methacholine PC(20) was lower in LSA than in RDA (0.44 versus 3.37 mg/ml) at baseline and improved similarly by 1.85 and 1.86 double concentrations with FP treatment. PC(20) normalized (>/= 16 mg/ml) in five patients with RDA and two patients with LSA. Baseline mean bronchial cell counts (per mm(2) connective tissue surface) for CD3(+), CD4(+), CD8(+), CD25(+), EG1(+), CD45ro(+), and AA1(+) cells were similar in both groups. With FP, EG1(+) (p < 0.001), EG2(+) (p = 0.018), and AA1(+) counts (p = 0.009) decreased significantly in both groups while CD45ro(+) (p = 0.02) counts decreased only in LSA. Baseline type 1 and type 3 collagen deposition underneath the basement membrane was similar in RDA and LSA and did not change significantly after FP. This study shows that recent compared to long-standing mild asthma is associated with a similar degree of airway inflammation and subepithelial fibrosis, and a similar improvement in airway hyperresponsiveness after 8 wk on high-dose ICS. It also indicates that once asthma becomes symptomatic, airway responsiveness cannot normalize in most subjects over such a time period, even with a high dose of ICS.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1073-449X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
162
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1308-13
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11029336-Administration, Inhalation,
pubmed-meshheading:11029336-Adolescent,
pubmed-meshheading:11029336-Adult,
pubmed-meshheading:11029336-Androstadienes,
pubmed-meshheading:11029336-Anti-Asthmatic Agents,
pubmed-meshheading:11029336-Asthma,
pubmed-meshheading:11029336-Basement Membrane,
pubmed-meshheading:11029336-Biopsy,
pubmed-meshheading:11029336-Bronchi,
pubmed-meshheading:11029336-Bronchial Hyperreactivity,
pubmed-meshheading:11029336-Bronchial Provocation Tests,
pubmed-meshheading:11029336-Bronchitis,
pubmed-meshheading:11029336-Bronchoscopy,
pubmed-meshheading:11029336-Collagen,
pubmed-meshheading:11029336-Epithelium,
pubmed-meshheading:11029336-Female,
pubmed-meshheading:11029336-Forced Expiratory Volume,
pubmed-meshheading:11029336-Humans,
pubmed-meshheading:11029336-Immunoenzyme Techniques,
pubmed-meshheading:11029336-Male
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma. Influence of inhaled corticosteroids.
|
| pubmed:affiliation |
Institut de Cardiologie et de Pneumologie de L'Université Laval, H opital Laval, Sainte-Foy, Québec, Canada. lpboulet@med.ulaval.ca
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|