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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-12-7
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pubmed:abstractText |
Liver-derived hyperleptinemia induced in normal rats by adenovirus-induced gene transfer causes rapid disappearance of body fat, whereas the endogenous adipocyte-derived hyperleptinemia of obesity does not. Here we induce liver-derived hyperleptinemia in rats with adipocyte-derived hyperleptinemia of acquired obesity caused by ventromedial hypothalamus lesioning (VMH rats) or by feeding 60% fat (DIO rats). Liver-derived hyperleptinemia in obese rats caused only a 5-7% loss of body weight, compared to a 13% loss in normoleptinemic lean animals; but in actual grams of weight lost there was no significant difference between obese and lean groups, suggesting that a subset of cells remain leptin-sensitive in obesity. mRNA and protein of a putative leptin-resistance factor, suppressor of cytokine signaling (SOCS)-1 or -3, were both increased in white adipose tissues (WAT) of VMH and DIO rats. Since transgenic overexpression of SOCS-3 in islets reduced the lipopenic effect of leptin by 75%, we conclude that the increased expression of SOCS-1 and -3 in WAT of rats with acquired obesity could have blocked leptin's lipopenic action in the leptin-resistant WAT population.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Socs1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Socs3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11027633-Adenoviridae,
pubmed-meshheading:11027633-Adipocytes,
pubmed-meshheading:11027633-Adipose Tissue,
pubmed-meshheading:11027633-Animals,
pubmed-meshheading:11027633-Carrier Proteins,
pubmed-meshheading:11027633-Diet,
pubmed-meshheading:11027633-Gene Transfer Techniques,
pubmed-meshheading:11027633-Islets of Langerhans,
pubmed-meshheading:11027633-Leptin,
pubmed-meshheading:11027633-Liver,
pubmed-meshheading:11027633-Male,
pubmed-meshheading:11027633-Obesity,
pubmed-meshheading:11027633-Proteins,
pubmed-meshheading:11027633-RNA, Messenger,
pubmed-meshheading:11027633-Rats,
pubmed-meshheading:11027633-Rats, Sprague-Dawley,
pubmed-meshheading:11027633-Rats, Zucker,
pubmed-meshheading:11027633-Repressor Proteins,
pubmed-meshheading:11027633-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:11027633-Transcription Factors,
pubmed-meshheading:11027633-Ventromedial Hypothalamic Nucleus
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pubmed:year |
2000
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pubmed:articleTitle |
Leptin resistance of adipocytes in obesity: role of suppressors of cytokine signaling.
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pubmed:affiliation |
Gifford Laboratories, Touchstone Center for Diabetes Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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