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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-10-12
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pubmed:abstractText |
The winged helix transcription factor Qin is the avian homolog of the mammalian brain factor 1 (BF-1) and has the potential to act as an oncogenic protein. We used representational difference analysis to identify genes that are differentially expressed in chicken embryo fibroblasts (CEF) transformed by Qin. One of the up-regulated Qin targets identified in this analysis is a serine-threonine kinase termed Qik (Qin-induced kinase). Qik belongs to the AMPK/SNF1 kinase family. It is a ubiquitously expressed protein and is upregulated rapidly after a hormone-regulated form of Qin is activated. In vitro kinase tests demonstrate that Qik is capable of autophosphorylation. Elevated levels of Qik transcripts are also observed in Src-transformed cells, suggesting that Src and Qin share some targets.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Avian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SNF1-related protein kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/v-qin protein, Avian sarcoma virus...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
276
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
564-70
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pubmed:dateRevised |
2011-6-6
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pubmed:meshHeading |
pubmed-meshheading:11027514-Amino Acid Sequence,
pubmed-meshheading:11027514-Animals,
pubmed-meshheading:11027514-Avian Proteins,
pubmed-meshheading:11027514-Base Sequence,
pubmed-meshheading:11027514-Cell Transformation, Neoplastic,
pubmed-meshheading:11027514-Chick Embryo,
pubmed-meshheading:11027514-DNA, Complementary,
pubmed-meshheading:11027514-Fibroblasts,
pubmed-meshheading:11027514-Forkhead Transcription Factors,
pubmed-meshheading:11027514-Genes, src,
pubmed-meshheading:11027514-Molecular Sequence Data,
pubmed-meshheading:11027514-Oncogene Proteins,
pubmed-meshheading:11027514-Phosphorylation,
pubmed-meshheading:11027514-Protein-Serine-Threonine Kinases,
pubmed-meshheading:11027514-Proto-Oncogene Proteins,
pubmed-meshheading:11027514-Sequence Homology, Amino Acid,
pubmed-meshheading:11027514-Up-Regulation,
pubmed-meshheading:11027514-Viral Proteins
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pubmed:year |
2000
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pubmed:articleTitle |
The new serine-threonine kinase, Qik, is a target of the Qin oncogene.
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pubmed:affiliation |
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC239, La Jolla, California 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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