Linked Life Data

11027224

Source:http://linkedlifedata.com/resource/pubmed/id/11027224

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
20
pubmed:dateCreated
2000-10-16
pubmed:abstractText
The tolerance and dependence after chronic medication with morphine are thought to be representative models for studying the plasticity, including the remodeling of neuronal networks. To test the hypothesis that changes in neuronal plasticity observed in opioid tolerance or dependence are derived from increased activity of the anti-opioid nociceptin system, the effects of chronic treatments with morphine were examined using nociceptin receptor knock-out (NOR(-/-)) mice and a novel nonpeptidic NOR antagonist, J-113397, which shows a specific and potent NOR antagonist activity in in vitro [(35)S]GTPgammaS binding assay and in vivo peripheral nociception test. The NOR(-/-) mice showed marked resistance to morphine analgesic tolerance without affecting morphine analgesic potency in tail-pinch and tail-flick tests. The NOR(-/-) mice also showed marked attenuation of morphine-induced physical dependence, manifested as naloxone-precipitated withdrawal symptoms after repeated morphine treatments. Similar marked attenuation of morphine tolerance was also observed by single subcutaneous (10 mg/kg) or intrathecal (1 nmol) injection of J-113397, which had been given 60 min before the test in morphine-treated ddY mice. However, the intracerebroventricular injection (up to 3 nmol) did not affect the tolerance. On the other hand, morphine dependence was markedly attenuated by J-113397 that had been subcutaneously given 60 min before naloxone challenge. There was also observed a parallel enhancement of NOR gene expression only in the spinal cord during chronic morphine treatments. Together, these findings suggest that the spinal NOR system develops anti-opioid plasticity observed on morphine tolerance and dependence.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7640-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11027224-Animals, pubmed-meshheading:11027224-Benzimidazoles, pubmed-meshheading:11027224-Binding, Competitive, pubmed-meshheading:11027224-Brain, pubmed-meshheading:11027224-Cell Membrane, pubmed-meshheading:11027224-Disease Models, Animal, pubmed-meshheading:11027224-Drug Administration Schedule, pubmed-meshheading:11027224-Drug Antagonism, pubmed-meshheading:11027224-Drug Tolerance, pubmed-meshheading:11027224-Guanosine 5'-O-(3-Thiotriphosphate), pubmed-meshheading:11027224-Male, pubmed-meshheading:11027224-Mice, pubmed-meshheading:11027224-Mice, Knockout, pubmed-meshheading:11027224-Morphine, pubmed-meshheading:11027224-Morphine Dependence, pubmed-meshheading:11027224-Naloxone, pubmed-meshheading:11027224-Narcotic Antagonists, pubmed-meshheading:11027224-Neuronal Plasticity, pubmed-meshheading:11027224-Opioid Peptides, pubmed-meshheading:11027224-Pain Measurement, pubmed-meshheading:11027224-Piperidines, pubmed-meshheading:11027224-Receptors, Opioid, pubmed-meshheading:11027224-Spinal Cord, pubmed-meshheading:11027224-Substance Withdrawal Syndrome
pubmed:year
2000
pubmed:articleTitle
Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence.
pubmed:affiliation
Department of Molecular Pharmacology and Neuroscience, Nagasaki University School of Pharmaceutical Sciences, Nagasaki 852-8521, Japan.ueda@net.nagasaki-u.ac.jp.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't