Linked Life Data

11024401

Source:http://linkedlifedata.com/resource/pubmed/id/11024401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2004-12-16
pubmed:abstractText
A morphometric comparison of the anatomic causes of left ventricular (LV) outflow obstruction in interruption of the aortic arch and in coarctation of the aorta with ventricular septal defect (VSD), based on 30 postmortem cases of each, revealed that posterior malalignment of the conal septum with a conoventricular VSD was significantly more prevalent with interruption (93%) than with coarctation (47%) (p <0.001). The ratio of the aortic valve diameter-to-the pulmonary valve diameter, which provided a quantitative index of the degree of posterior conal septal malalignment and of the consequent LV outflow tract obstruction at and immediately below the level of the aortic valve, was significantly smaller with interruption (</=0.50 in 67%) than with coarctation (</=0.50 in 17%) (p <0.001). A bicuspid or unicuspid aortic valve, both with interruption and with coarctation, was more prevalent with posterior conal septal malalignment (74%) than with normal conal septal alignment (42%) (p <0.05). Posterior conal septal malalignment was associated with LV outflow tract obstruction at 3 different sites: subvalvar, annular, and leaflet. The anatomic findings explain the incidence of postoperative LV outflow tract obstruction in patients with interrupted aortic arch after simple VSD closure, and may support a surgical strategy of elevating or otherwise removing the posteriorly malaligned conal septum from the LV outflow tract at the time of VSD closure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
856-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Comparison of left ventricular outflow tract obstruction in interruption of the aortic arch and in coarctation of the aorta, with diagnostic, developmental, and surgical implications.
pubmed:affiliation
Department of Cardiology, Children's Hospital, Boston, Massachusetts, USA.
pubmed:publicationType
Journal Article, Comparative Study