Linked Life Data

11023616

Source:http://linkedlifedata.com/resource/pubmed/id/11023616

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-12-28
pubmed:abstractText
The effects of the cholinesterase inhibitor neostigmine on the responses to vagus nerve stimulation of isolated sinus venosus/atrial preparations of the toad, Bufo marinus, were examined. In control solutions, trains of stimuli applied to the vagus nerve led to a decrease in heart rate that was susceptible to muscarinic receptor blockade. Membrane potential recordings made from sinus venosus cells showed that the responses to trains of stimuli, delivered at frequencies of less than 10 Hz, were little changed by the addition of neostigmine. However, the responses to longer trains of stimuli at 10 Hz (30 versus 10 s) were potentiated and the nature of the membrane potential changes was altered. The results suggest that, due to the activity of cholinesterases, acetylcholine (ACh) released from parasympathetic nerves normally has little access to the muscarinic receptors in the pacemaker region, which are linked to potassium channels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1566-0702
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-14
pubmed:dateRevised
2009-8-12
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Potentiation by neostigmine of responses to vagal nerve stimulation in the sinus venosus of the toad.
pubmed:affiliation
Department of Zoology, University of Melbourne, Parkville, Victoria, Australia. n.bramich@zoology.unimelb.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't