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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-11-9
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pubmed:abstractText |
Chromosomal translocation involving the BCL6 gene affects not only immunoglobulin (Ig) genes but also a number of non-Ig genes as partners. The molecular anatomy of the BCL6 gene rearrangements in 39 cases with diffuse large B-cell lymphoma (DLBCL) by long-distance polymerase chain reaction-based assays was determined. The results showed that Ig genes were affected in 21 cases; non-Ig genes, 15 cases; a deletion of more than a 1-kb segment, 2 cases; and a point mutation, 1 case. Comparative studies between the 21 cases with Ig gene partners and the 17 cases with non-Ig gene partners, including 2 cases with the deletion, showed that the overall survival of the latter group of patients was significantly inferior to that of the former (P = .0440), and the estimated 2-year overall survival rates were 58.3% vs 17.6% (P = .005). Non-Ig/BCL6 fusion is a poor prognostic indicator of DLBCL, and DLBCL with BCL6 translocation could be subclassified according to the individual partner locus and/or gene. (Blood. 2000;96:2907-2909)
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2907-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11023530-Adult,
pubmed-meshheading:11023530-Aged,
pubmed-meshheading:11023530-Chromosomes, Human, Pair 1,
pubmed-meshheading:11023530-Chromosomes, Human, Pair 14,
pubmed-meshheading:11023530-Chromosomes, Human, Pair 16,
pubmed-meshheading:11023530-Chromosomes, Human, Pair 3,
pubmed-meshheading:11023530-Chromosomes, Human, Pair 7,
pubmed-meshheading:11023530-DNA, Neoplasm,
pubmed-meshheading:11023530-DNA Mutational Analysis,
pubmed-meshheading:11023530-DNA-Binding Proteins,
pubmed-meshheading:11023530-Female,
pubmed-meshheading:11023530-Genes, Immunoglobulin,
pubmed-meshheading:11023530-Humans,
pubmed-meshheading:11023530-Life Tables,
pubmed-meshheading:11023530-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:11023530-Male,
pubmed-meshheading:11023530-Middle Aged,
pubmed-meshheading:11023530-Point Mutation,
pubmed-meshheading:11023530-Polymerase Chain Reaction,
pubmed-meshheading:11023530-Prognosis,
pubmed-meshheading:11023530-Proto-Oncogene Proteins,
pubmed-meshheading:11023530-Proto-Oncogene Proteins c-bcl-6,
pubmed-meshheading:11023530-Sequence Deletion,
pubmed-meshheading:11023530-Survival Analysis,
pubmed-meshheading:11023530-Survival Rate,
pubmed-meshheading:11023530-Transcription Factors,
pubmed-meshheading:11023530-Translocation, Genetic
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pubmed:year |
2000
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pubmed:articleTitle |
Nonimmunoglobulin (non-Ig)/BCL6 gene fusion in diffuse large B-cell lymphoma results in worse prognosis than Ig/BCL6.
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pubmed:affiliation |
First Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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