Linked Life Data

11021975

Source:http://linkedlifedata.com/resource/pubmed/id/11021975

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2001-1-26
pubmed:abstractText
Our previous studies have demonstrated that supraspinal glutamate receptors are differentially involved in the antinociception induced by morphine and beta-endorphin given intracerebroventricularly (i.c.v.) in the tail-flick and hot-plate tests. The formalin pain test was used in the present study. Injection of mice with formalin solution (2%, 10 microl) into the hindpaw intraplantarly produced the first (0-5 min) and second (20-40 min) phases of formalin responses. The formalin responses in the both phases were attenuated dose-dependently by morphine (0.125-1 microg) or beta-endorphin (0.125-1 microg) administered i.c.v. 5 min before. The antinociceptive effect of morphine was slightly more potent in the second phase whereas the effect of beta-endorphin was more pronounced in the first phase. MK-801 (0.1-1 microg), a non-competitive NMDA receptor antagonist, and CNQX (0.05-0.5 microg), a non-NMDA antagonist, given i.c.v., produced antinociceptive effect in the both phases, but only in a partial manner. Both MK-801 (0.05 microg) and CNQX (0.01 microg), at the dose which had no intrinsic effect, reversed the antinociceptive effect of beta-endorphin (1 microg) observed during the second, but not the first, phase partially but significantly. However, the antinociceptive effect of morphine (1 microg) was not affected by the same dose of MK-801 or CNQX given i.c.v. Our results indicate that, at the supraspinal level, both NMDA and non-NMDA receptors are involved in the production of antinociception induced by supraspinally administered beta-endorphin, but not morphine, in the formalin pain model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0143-4179
pubmed:author
pubmed:copyrightInfo
Copyright 2000 Harcourt Publishers Ltd.
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
158-66
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11021975-6-Cyano-7-nitroquinoxaline-2,3-dione, pubmed-meshheading:11021975-Analgesics, pubmed-meshheading:11021975-Animals, pubmed-meshheading:11021975-Brain, pubmed-meshheading:11021975-Cerebral Ventricles, pubmed-meshheading:11021975-Disease Models, Animal, pubmed-meshheading:11021975-Dizocilpine Maleate, pubmed-meshheading:11021975-Excitatory Amino Acid Antagonists, pubmed-meshheading:11021975-Formaldehyde, pubmed-meshheading:11021975-Injections, Intraventricular, pubmed-meshheading:11021975-Male, pubmed-meshheading:11021975-Mice, pubmed-meshheading:11021975-Mice, Inbred ICR, pubmed-meshheading:11021975-Morphine, pubmed-meshheading:11021975-Pain, pubmed-meshheading:11021975-Receptors, Glutamate, pubmed-meshheading:11021975-Receptors, N-Methyl-D-Aspartate, pubmed-meshheading:11021975-Spinal Cord, pubmed-meshheading:11021975-beta-Endorphin
pubmed:articleTitle
Supraspinal NMDA and non-NMDA receptors are differentially involved in the production of antinociception by morphine and beta-endorphin administered intracerebroventricularly in the formalin pain model.
pubmed:affiliation
Department of Pharmacology and Institute of Natural Medicine, College of Medicine, Hallym University, 1 Okchun-Dong, Chunchon, Kangwon-Do 200-702, S. Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't