| pubmed-article:11018755 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11018755 | lifeskim:mentions | umls-concept:C0034650 | lld:lifeskim |
| pubmed-article:11018755 | lifeskim:mentions | umls-concept:C0034652 | lld:lifeskim |
| pubmed-article:11018755 | lifeskim:mentions | umls-concept:C0039597 | lld:lifeskim |
| pubmed-article:11018755 | lifeskim:mentions | umls-concept:C0082529 | lld:lifeskim |
| pubmed-article:11018755 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:11018755 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11018755 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11018755 | pubmed:dateCreated | 2000-11-9 | lld:pubmed |
| pubmed-article:11018755 | pubmed:abstractText | Several lines of evidence support a key role of estradiol-17beta (E(2)) in male fertility. We have used a non-mammalian vertebrate model, the frog Rana esculenta, to investigate the regulation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) activity in the testis during the annual sexual cycle and to study whether E(2 )exerts a role in spermatogenesis through the regulation of ERK1/2 activity. ERK1/2 proteins are present in the cytoplasm and nucleus of the primary and secondary spermatogonia (SPG), and in the nucleus of primary spermatocytes. The annual E(2) profile shows a progressive increase during active spermatogenesis with a peak in the month of June. In parallel, ERK1/2 are highly phosphorylated during the period of active spermatogenesis (from April to July) compared with the regressive period (September/October) and winter stasis (from November to March). E(2) treatment induces the proliferation of primary SPG, possibly via the activation of ERK1/2, and this effect is counteracted by the anti-estrogen ICI 182-780. | lld:pubmed |
| pubmed-article:11018755 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11018755 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11018755 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11018755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11018755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11018755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11018755 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11018755 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11018755 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11018755 | pubmed:issn | 0022-0795 | lld:pubmed |
| pubmed-article:11018755 | pubmed:author | pubmed-author:FrancoRR | lld:pubmed |
| pubmed-article:11018755 | pubmed:author | pubmed-author:TramontanoDD | lld:pubmed |
| pubmed-article:11018755 | pubmed:author | pubmed-author:ChieffoVV | lld:pubmed |
| pubmed-article:11018755 | pubmed:author | pubmed-author:StaibanoSS | lld:pubmed |
| pubmed-article:11018755 | pubmed:author | pubmed-author:Colucci-D'Ama... | lld:pubmed |
| pubmed-article:11018755 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11018755 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:11018755 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11018755 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11018755 | pubmed:pagination | 77-84 | lld:pubmed |
| pubmed-article:11018755 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:meshHeading | pubmed-meshheading:11018755... | lld:pubmed |
| pubmed-article:11018755 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11018755 | pubmed:articleTitle | Estradiol-induced mitogen-activated protein kinase (extracellular signal-regulated kinase 1 and 2) activity in the frog (Rana esculenta) testis. | lld:pubmed |
| pubmed-article:11018755 | pubmed:affiliation | Dipartimento di Fisiologia Umana e Funzioni Biologiche Integrate 'F. Bottazzi' II, Università di Napoli, Naples, Italy. Paolo.Chieffi@unina2.it | lld:pubmed |
| pubmed-article:11018755 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11018755 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11018755 | lld:pubmed |
