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rdf:type |
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lifeskim:mentions |
umls-concept:C0012854,
umls-concept:C0013879,
umls-concept:C0017263,
umls-concept:C0017337,
umls-concept:C0021853,
umls-concept:C0022646,
umls-concept:C0025936,
umls-concept:C0081937,
umls-concept:C0086860,
umls-concept:C0205107,
umls-concept:C0205147,
umls-concept:C0205410,
umls-concept:C0441655,
umls-concept:C0449719,
umls-concept:C0936012,
umls-concept:C1416522
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-11-8
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pubmed:abstractText |
The dipeptidyl peptidase IV (DPPIV) gene encodes a brush border membrane exopeptidase that is expressed in a tissue-restricted fashion. To examine the regulation of DPPIV transcription in various tissues in vivo, we examined the expression of DPPIV 5'-flanking region (promoter)-human growth hormone reporter constructs in transgenic mice. These mice exhibited cell-type specific reporter expression in kidney. Surprisingly, however, only very low to non-detectable levels of reporter were found in small intestine. These results indicate that DNA elements sufficient for DPPIV expression in kidney, but not intestine, reside in the 5'-flanking region of the gene.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
482
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-53
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11018521-5' Untranslated Regions,
pubmed-meshheading:11018521-Animals,
pubmed-meshheading:11018521-Base Sequence,
pubmed-meshheading:11018521-Dipeptidyl Peptidase 4,
pubmed-meshheading:11018521-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:11018521-Genes, Reporter,
pubmed-meshheading:11018521-Human Growth Hormone,
pubmed-meshheading:11018521-Humans,
pubmed-meshheading:11018521-Intestine, Small,
pubmed-meshheading:11018521-Kidney,
pubmed-meshheading:11018521-Mice,
pubmed-meshheading:11018521-Mice, Inbred BALB C,
pubmed-meshheading:11018521-Mice, Inbred C57BL,
pubmed-meshheading:11018521-Mice, Transgenic,
pubmed-meshheading:11018521-Molecular Sequence Data,
pubmed-meshheading:11018521-Organ Specificity,
pubmed-meshheading:11018521-Promoter Regions, Genetic,
pubmed-meshheading:11018521-RNA, Messenger,
pubmed-meshheading:11018521-Transcription, Genetic
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pubmed:year |
2000
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pubmed:articleTitle |
Analysis of dipeptidyl peptidase IV gene regulation in transgenic mice: DNA elements sufficient for promoter activity in the kidney, but not the intestine, reside on the proximal portion of the gene 5'-flanking region.
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pubmed:affiliation |
Gastrointestinal Research Laboratory, Department of Veterans' Affairs Medical Center, San Francisco, CA 94121, USA. jgum@maelstrom.ucsf.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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