Source:http://linkedlifedata.com/resource/pubmed/id/11018519
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2000-11-8
|
| pubmed:abstractText |
We cloned a major isoform of Xenopus homologue of cold inducible RNA binding protein (CIRP), XCIRP-1. XCIRP-1 was neither cold inducible nor essential for cell division during early embryonic development. Suppression of XCIRP-1 dose dependently produced tailbuds with deformations of the brain and internal organs. The defects were XCIRP-1 specific as they could be rescued by sense transcript. Suppression of XCIRP-1 also disrupted the morphogenetic migration of the C3 blastomeres (lineaged to become the embryonic kidney, the pronephros). In animal cap explants, depletion of XCIRP-1 inhibited activin/retinoic acid induced expressions of pronephros related Xlim-1 and WT1 genes. These results suggest that XCIRP-1 is required for the specification and morphogenetic lineage migration of the pronephros.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0014-5793
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
482
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
37-43
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11018519-Abnormalities, Multiple,
pubmed-meshheading:11018519-Animals,
pubmed-meshheading:11018519-Cell Division,
pubmed-meshheading:11018519-Cloning, Molecular,
pubmed-meshheading:11018519-Embryo, Nonmammalian,
pubmed-meshheading:11018519-Evolution, Molecular,
pubmed-meshheading:11018519-Female,
pubmed-meshheading:11018519-Kidney,
pubmed-meshheading:11018519-Morphogenesis,
pubmed-meshheading:11018519-Phenotype,
pubmed-meshheading:11018519-Phylogeny,
pubmed-meshheading:11018519-Protein Isoforms,
pubmed-meshheading:11018519-RNA-Binding Proteins,
pubmed-meshheading:11018519-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11018519-Suppression, Genetic,
pubmed-meshheading:11018519-Transcription, Genetic,
pubmed-meshheading:11018519-Xenopus Proteins,
pubmed-meshheading:11018519-Xenopus laevis
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Maternal cold inducible RNA binding protein is required for embryonic kidney formation in Xenopus laevis.
|
| pubmed:affiliation |
Department of Neurology, The First Military Medical University of China, Guangzhou, PR China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|